Recombinant Human Stromelysin-3 (MMP11)

中文名稱：

Recombinant Human Stromelysin-3 (MMP11)
品名簡稱：

Recombinant Human MMP11 protein
貨號：

CSB-EP014658HU
說明書：

MSDS Datasheet
規格：

￥1836
圖片：
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

Greater than 85% as determined by SDS-PAGE.
生物活性：

Not Test
基因名：

MMP11
Uniprot No.：

P24347
別名：

Matrix metalloproteinase-11
種屬：

Homo sapiens (Human)
蛋白長度：

Full Length of Mature Protein
來源：

E.coli
分子量：

51.2 kDa
表達區域：

98-488aa
氨基酸序列

FVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEALKVWSDVTPLTFTEVHEGRADIMIDFARYWHGDDLPFDGPGGILAHAFFPKTHREGDVHFDYDETWTIGDDQGTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYTFRYPLSLSPDDCRGVQHLYGQPWPTVTSRTPALGPQAGIDTNEIAPLEPDAPPDACEASFDAVSTIRGELFFFKAGFVWRLRGGQLQPGYPALASRHWQGLPSPVDAAFEDAQGHIWFFQGAQYWVYDGEKPVLGPAPLTELGLVRFPVHAALVWGPEKNKIYFFRGRDYWRFHPSTRRVDSPVPRRATDWRGVPSEIDAAFQDADGYAYFLRGRLYWKFDPVKVKALEGFPRLVGPDFFGCAEPANTFL
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

C-terminal 6xHis-tagged
產品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 3-7 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

May play an important role in the progression of epithelial malignancies.
基因功能參考文獻：
1. We believe that genetic variations in the MMP-11 gene may help to predict early-stage Hepatocellular carcinoma and act as reliable biomarkers for Hepatocellular carcinoma progression PMID: 29725257
2. In this study, matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) has been used for the first time to investigate the distribution of MMP-11 in human breast cancer tissues in order to show a possible correlation between cancerous and healthy samples, by differential proteomics and using such differences for possible cancer diagnosis and/or prognosis. PMID: 28801789
3. Authors evaluated the expression of known targets of miR-125a and found that sirtuin-7, matrix metalloproteinase-11, and c-Raf were up-regulated in tumor tissue by 2.2-, 3-, and 1.7-fold, respectively. Overall, these data support a tumor suppressor role for miR-125a. PMID: 28445974
4. Results revealed that MMP-11 high expression in oral squamous cell carcinoma (OSCC) samples can predict the progression, especially lymph node metastasis, and the survival of OSCC patients. PMID: 28427180
5. A new prognostic model for HR-/HER2+ breast cancer based on the expression of MMP11 and CD2 was developed and the distant metastasis-free survival for patients in the high-risk group according to our model was significantly lower than that for those in the low-risk group. PMID: 28409241
6. HMGA1 and MMP-11 may play a key role in the proliferation and progression of skin tumors in humans. PMID: 29374701
7. These results demonstrated that miR-145 has an inhibitory role in TNBC malignancy by targeting MMP11 and Rab27a, which might be potential therapeutic and diagnostic targets for TNBC. PMID: 27364572
8. the data demonstrate that miR125a5p functions as a tumor suppressor gene and serves an important role in inhibiting osteosarcoma cell migration, invasion and EMT by targeting MMP11. PMID: 27081863
9. MMP-11 overexpression is associated with aggressive tumor phenotype and unfavorable clinical outcome in urothelial carcinomas. PMID: 26861489
10. Our study established that high serum levels of MMP-11 are associated with poor clinical outcome and may serve as a prognostic biomarker in colon cancer patients. PMID: 27002762
11. Overexpression of MMP-11 was discovered in sera of cancer patients compared with normal control group as well as in multiple tumor tissue specimens, such as gastric cancer, breast cancer, and pancreatic cancer. At present, some evidence supports that MMP-11 may work as a significant tumor biomarker for early detection of cancer, tumor staging, prognostic analysis, monitoring recurrence [review] PMID: 26892540
12. Matrix metalloproteinase 11 has a role in degenerating intervertebral disc disease PMID: 26956825
13. combined effects of the MMP-11 gene polymorphisms and environmental carcinogens are related to an increased risk for the development of OSCC and may be a predictive factor for tumor lymph node metastasis in Taiwanese with OSCC PMID: 24838924
14. results indicated that both CD147 and MMP-11 may be involved in the progression of colorectal cancer, and they are potential prognostic factors and might become new therapeutic targets for CRC patients PMID: 26507719
15. Our findings identified these 2 genes as a novel breast cancer biomarker gene set, which may facilitate the diagnosis and treatment in breast cancer clinical therapies. PMID: 26084486
16. High Expression of Matrix Metalloproteinase-11 is associated with Cholangiocarcinoma. PMID: 25987024
17. study showed that plasma level of MMP-11 may be useful for assessment of the disease progression, especially lymph node metastasis, in patients with OSCC PMID: 25423087
18. MMP-14 function might represent one critical regulatory mechanism to control the extent of pericellular MMP-11 bioavailability and protect cells from excessive/inappropriate MMP-11 function. PMID: 25081520
19. These findings further suggest MMP11 as a promising biomarker for breast and prostate cabcer. PMID: 24564996
20. MMP-11 expression was significantly related to clinicopathological parameters, which may be essential to the prediction of disease outcome in patients with invasive ductal carcinoma of the breast. PMID: 23115007
21. Knockdown of MMP11 expression could inhibit the proliferation and invasion of gastric adenocarcinoma cells probably through down-regulation of the IGF-1 signaling pathway. PMID: 23755751
22. Findings define a regulatory role of miR-98 in tumor angiogenesis and invasion through repressed ALK4 and MMP11 expression. PMID: 23211491
23. Data suggest that intra- and extracellular tracking of MMP-11-overexpressing cancer cells might contribute to the understanding of the activation pathways leading to MMP-11-mediated invasive processes. PMID: 22927434
24. MiR-125a inhibits the proliferation and metastasis of hepatocellular carcinoma by targeting MMP11 and VEGF-A. PMID: 22768249
25. expression by fibroblasts associated with poor prognosis in colorectal cancer PMID: 22488635
26. Results describe MMP-11 expression in human epithelial colon adenocarcinoma cell lines (Caco-2, HT-29 and BCS-TC2). PMID: 22227581
27. Report MMP11/12 expression in cervical scrapes cells from cervical precursor lesions. PMID: 22076168
28. MMP11 (metalloproteinase 11) gene shows increased expression in papillary thyroid cancer. PMID: 17091452
29. MMP-11 is overexpressed in many lobular carcinoma cells, and it may play role in lobular carcinogenesis through increasing resistance to anoikis. PMID: 21773755
30. Serum levels in Chinese patients with advanced gastric carcinoma are not associated with the response to chemotherapy, but play role in lymph node metastasis and prognosis PMID: 21513571
31. The MMP-11 is up-regulated by Gli1 and mediates the migration and invasion induced by Gli1 in MDA-MB-231. PMID: 21442356
32. The expression of stromelysin-3 was closely associated with the invasion and metastasis of laryngeal carcinoma. PMID: 18476627
33. matrix metalloproteinase 11 is a novel factor in the development and progression of gastric cancer and suggest that matrix metalloproteinase 11 is a marker for advanced gastric cancer. PMID: 20060156
34. the results of this study indicate that MMP11 polymorphism may be associated with Kawasaki disease in the Korean population PMID: 20230842
35. High expression of MMP-11 or -13, or cluster thereof, were significantly associated with higher probability of biochemical recurrence in prostate cancer PMID: 20160732
36. MMP-11 and CK-20 are probable prognostic markers whose expression reflects the stages of tumor differentiation and LNM of breast cancer. PMID: 19914229
37. may play role in meningioma invasiveness PMID: 11857311
38. alternative splicing and promoter usage generates an intracellular stromelysin 3 isoform directly translated as an active matrix metalloproteinase PMID: 12006591
39. Data confirmed stromelysin-3's contribution to breast cancer progression and its expression was shown to have a direct negative effect on patients' survival. PMID: 12429794
40. MMP11 may have a role in the pathogenesis of papillary thyroid carcinoma PMID: 12538453
41. Active stromelysin-3 increases breast cancer cell survival in three-dimensional Matrigel culture via activation of p42/p44 MAP-kinase PMID: 12845673
42. ST3 protein was more involved in the pathway of colorectal cancer development in females, distal locations, infiltrative growth patterns and microsatellite stability. PMID: 15459498
43. central role of PKC isoforms and the negative regulatory function of c-Src in the control of ST3 expression PMID: 15509588
44. colony formation of MMP11 deficient cells was dramatically inhibited in soft agar and tumorigenicity was reduced in nude mice, respectively PMID: 15582574
45. cathepsin F, matrix metalloproteinases 11 and 12 are upregulated in cervical cancer PMID: 15989693
46. MMP-11, like an inflammatory mediator, may exert a chemotactic influence on macrophages which aggregate in the mesangium; MMP-11 is not likely to have a parallel mitogenic or antifibrotic effect in diseased glomeruli PMID: 17085465
47. proposes that ST-3 induction in tumour fibroblasts leads to the stimulation of the IGF-1R pathway in carcinoma cells, thus enhancing their proliferative capacity PMID: 17233884
48. MMP11 may play an important role in carcinogenesis and has potential implication as a biomarker for the diagnosis and prognosis of human cancers including gastric cancer. PMID: 18172255
49. MMP11 exhibits collagenolytic function against collagen VI under malignant conditions. PMID: 18622425
50. MMP-11 were identified at higher levels in lung secretions of pediatric ALI patients compared with controls. PMID: 19159011
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亞細胞定位：

Secreted, extracellular space, extracellular matrix.
蛋白家族：

Peptidase M10A family
組織特異性：

Specifically expressed in stromal cells of breast carcinomas.
數據庫鏈接：

HGNC: 7157

OMIM: 185261

KEGG: hsa:4320

STRING: 9606.ENSP00000215743

UniGene: Hs.143751