Recombinant Human Sodium-driven chloride bicarbonate exchanger (SLC4A10), partial

中文名稱：

人SLC4A10重組蛋白
貨號(hào)：

CSB-YP740896HU
規(guī)格：
來源：

Yeast
其他：

中文名稱：

人SLC4A10重組蛋白
貨號(hào)：

CSB-EP740896HU
規(guī)格：
來源：

E.coli
其他：

中文名稱：

人SLC4A10重組蛋白
貨號(hào)：

CSB-EP740896HU-B
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人SLC4A10重組蛋白
貨號(hào)：

CSB-BP740896HU
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

人SLC4A10重組蛋白
貨號(hào)：

CSB-MP740896HU
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

SLC4A10
Uniprot No.：

Q6U841
別名：

NBCn 2; NBCn2; NCBE; S4A10; S4A10_HUMAN; SLC 4A10; SLC4 A10; SLC4A 10; Slc4a10; Sodium driven chloride bicarbonate exchanger; Sodium-driven chloride bicarbonate exchanger; Solute carrier family 4 member 10; Solute carrier family 4, sodium bicarbonate cotransporter like, member 10; Solute carrier family 4, sodium bicarbonate transporter like, member 10; Solute carrier family 4, sodium bicarbonate transporter, member 10
種屬：

Homo sapiens (Human)
蛋白長(zhǎng)度：

Partial
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Sodium/bicarbonate cotransporter which plays an important role in regulating intracellular pH. Has been shown to act as a sodium/bicarbonate cotransporter in exchange for intracellular chloride. Has also been shown to act as a sodium/biocarbonate cotransporter which does not couple net influx of bicarbonate to net efflux of chloride, with the observed chloride efflux being due to chloride self-exchange. Controls neuronal pH and may contribute to the secretion of cerebrospinal fluid. Reduces the excitability of CA1 pyramidal neurons and modulates short-term synaptic plasticity. Required in retinal cells to maintain normal pH which is necessary for normal vision. In the kidney, likely to mediate bicarbonate reclamation in the apical membrane of the proximal tubules.
基因功能參考文獻(xiàn)：
1. genetic variation in SLC4A10 expression and function in the central nervous system may affect the regulation of systemic water balance PMID: 28360221
2. There was no association between common sequence variants in the AQP1 or SLC4A10 genes and primary open-angle glaucoma in the Caucasian population. PMID: 20101282
3. propose to rename NCBE as the second electroneutral Na/HCO(3) cotransporter, NBCn2 PMID: 18319254
4. SLC4A10 (OMIM 605556), a sodium bicarbonate transporter gene with high expression in the cerebral cortex and hippocampus, was disrupted by the translocation breakpoint on chromosome 2q24. PMID: 18413482
亞細(xì)胞定位：

Basolateral cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Cell projection, dendrite. Cell projection, axon. Perikaryon. Cell junction, synapse, presynapse. Cell junction, synapse, postsynapse.
蛋白家族：

Anion exchanger (TC 2.A.31) family
組織特異性：

Predominantly expressed in the brain.
數(shù)據(jù)庫鏈接：

HGNC: 13811

OMIM: 605556

KEGG: hsa:57282

STRING: 9606.ENSP00000393066

UniGene: Hs.333958