Recombinant Human Small G protein signaling modulator 2 (SGSM2), partial

中文名稱：

人SGSM2重組蛋白
貨號：

CSB-YP021202HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人SGSM2重組蛋白
貨號：

CSB-EP021202HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人SGSM2重組蛋白
貨號：

CSB-EP021202HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人SGSM2重組蛋白
貨號：

CSB-BP021202HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人SGSM2重組蛋白
貨號：

CSB-MP021202HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

SGSM2
Uniprot No.：

O43147
別名：

D630003G22Rik; KIAA0397; mKIAA0397; R74628; RP23-174M12.3; RUN and TBC1 domain containing 1; RUN and TBC1 domain-containing protein 1; RUTBC1; Sgsm2; SGSM2_HUMAN; Small G protein signaling modulator 2; Small G protein signaling modulator 2 protein
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Possesses GTPase activator activity towards RAB32, RAB33B and RAB38. Regulates the trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes by inactivating RAB32 and RAB38. Inhibits RAB32 and RAB38 activation both directly by promoting their GTPase activity and indirectly by disrupting the RAB9A-HPS4 interaction which is required for RAB32/38 activation.
基因功能參考文獻：
1. Data suggest RUTBC1/SGSM2 in melanocytes functions as physiological GTPase-activating protein for Rab32/Rab38 in regulation of transport of melanogenic enzymes (tyrosinase, tyrosinase-related protein 1, dopachrome isomerase) into melanosomes. PMID: 26620560
2. Identification of novel protein SGSM2 which modulate small G protein (RAP and RAB)-mediated signaling pathway PMID: 17509819
亞細胞定位：

Cytoplasm. Melanosome.
蛋白家族：

RUTBC family
組織特異性：

Widely expressed.
數據庫鏈接：

HGNC: 29026

OMIM: 611418

KEGG: hsa:9905

STRING: 9606.ENSP00000268989

UniGene: Hs.513861