Recombinant Human Serine/threonine-protein kinase N3 (PKN3), partial

中文名稱：

人PKN3重組蛋白
貨號：

CSB-YP744059HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人PKN3重組蛋白
貨號：

CSB-EP744059HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人PKN3重組蛋白
貨號：

CSB-EP744059HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人PKN3重組蛋白
貨號：

CSB-BP744059HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人PKN3重組蛋白
貨號：

CSB-MP744059HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
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靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

PKN3
Uniprot No.：

Q6P5Z2
別名：

pkn3; PKN3_HUMAN; PKNBETA; Protein kinase C related kinase 3 ; Protein kinase N3; Protein kinase PKN beta; Protein kinase PKN-beta; Protein-kinase C-related kinase 3; RP11-545E17.1; Serine/threonine protein kinase N3; Serine/threonine-protein kinase N3
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Contributes to invasiveness in malignant prostate cancer.
基因功能參考文獻：
1. Steady-state kinetic analysis revealed that PKN1-3 follows a sequential ordered Bi-Bi kinetic mechanism, where peptide substrate binding is preceded by ATP binding. This kinetic mechanism was confirmed by additional kinetic studies for product inhibition and affinity of small molecule inhibitors. PMID: 27919031
2. PKN3 is the major regulator of angiogenesis in humans and mice and tumor metastasis in mice. PMID: 26742562
3. PKN3 can be considered a novel protein implicated in remodeling the actin-adherens junction, possibly by linking ICAM-1-signaling with actin/AJ dynamics. PMID: 22609186
4. PKN isoforms are not simply redundant in supporting migration, but appear to be linked through isoform specific regulatory domain properties to selective upstream signals. It PMID: 21754995
5. PKN3 might represent a preferred target for therapeutic intervention in cancers that lack tumor suppressor PTEN function or depend on chronic activation of phosphoinositide 3-kinase PMID: 15282551
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亞細胞定位：

Nucleus. Cytoplasm, perinuclear region. Note=Nuclear and perinuclear Golgi region.
蛋白家族：

Protein kinase superfamily, AGC Ser/Thr protein kinase family, PKC subfamily
組織特異性：

Expressed in prostate tumors and various cancer cell lines. Not expressed in adult tissues.
數據庫鏈接：

HGNC: 17999

OMIM: 610714

KEGG: hsa:29941

STRING: 9606.ENSP00000291906

UniGene: Hs.300485