Recombinant Human Rhomboid domain-containing protein 1 (RHBDD1), partial

中文名稱：

人RHBDD1重組蛋白
貨號：

CSB-YP823471HU1
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人RHBDD1重組蛋白
貨號：

CSB-EP823471HU1
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人RHBDD1重組蛋白
貨號：

CSB-EP823471HU1-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人RHBDD1重組蛋白
貨號：

CSB-BP823471HU1
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人RHBDD1重組蛋白
貨號：

CSB-MP823471HU1
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

RHBDD1
Uniprot No.：

Q8TEB9
別名：

RHBDD1; RHBDL4; HSD-50; HSD50; Rhomboid-related protein 4; RRP4; Rhomboid domain-containing protein 1; Rhomboid-like protein 4
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Intramembrane-cleaving serine protease that cleaves single transmembrane or multi-pass membrane proteins in the hydrophobic plane of the membrane, luminal loops and juxtamembrane regions. Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded membrane proteins. Required for the degradation process of some specific misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Functions in BIK, MPZ, PKD1, PTCRA, RHO, STEAP3 and TRAC processing. Involved in the regulation of exosomal secretion; inhibits the TSAP6-mediated secretion pathway. Involved in the regulation of apoptosis; modulates BIK-mediated apoptotic activity. Also plays a role in the regulation of spermatogenesis; inhibits apoptotic activity in spermatogonia.
基因功能參考文獻：
1. Tissue microarray assays demonstrated a correlation between RHBDD1 and EGFR in colorectal cancer patients. Therefore, our findings indicate that RHBDD1 stimulates EGFR expression by promoting the AP-1 pathway. PMID: 28445956
2. RHBDL4-mediated APP processing provides insight into APP and rhomboid physiology and qualifies for further investigations to elaborate its impact on Alzheimer disease pathology. PMID: 27563067
3. this study shows that RHBDD1 gene engineering could be used as an effective tool in malignant brain tumor therapy. PMID: 23883433
4. Our data show that in vitro RHBDD1 silencing regulates HepG2 cell proliferation and apoptosis. PMID: 23534782
5. RHBDD1 could inhibit cell apoptosis by activating and upregulating c-Jun and its downstream target, Bcl-3 PMID: 23669365
6. RHBDD1 is involved in the regulation of a nonclassical exosomal secretion pathway through the restriction of TSAP6. PMID: 22624035
7. RHBDD1, a serine protease, modulates BIK-mediated apoptotic activity. PMID: 18953687
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亞細胞定位：

Endoplasmic reticulum membrane; Multi-pass membrane protein. Mitochondrion membrane; Multi-pass membrane protein.
蛋白家族：

Peptidase S54 family
組織特異性：

Expressed strongly in testis.
數據庫鏈接：

HGNC: 23081

OMIM: 617515

KEGG: hsa:84236

STRING: 9606.ENSP00000344779

UniGene: Hs.471514