Recombinant Human Retinol-binding protein 3 (RBP3), partial

中文名稱：

人RBP3重組蛋白
貨號：

CSB-YP019482HU
規格：
來源：

Yeast
其他：

中文名稱：

人RBP3重組蛋白
貨號：

CSB-EP019482HU
規格：
來源：

E.coli
其他：

中文名稱：

人RBP3重組蛋白
貨號：

CSB-EP019482HU-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人RBP3重組蛋白
貨號：

CSB-BP019482HU
規格：
來源：

Baculovirus
其他：

中文名稱：

人RBP3重組蛋白
貨號：

CSB-MP019482HU
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

RBP3
Uniprot No.：

P10745
別名：

D10S64; D10S65; D10S66; Interphotoreceptor retinoid binding protein; Interphotoreceptor retinoid-binding protein; Interstitial retinol binding protein; Interstitial retinol-binding protein; IRBP; RBP 3; rbp3; RBPI; RET3_HUMAN; Retinol binding protein 3; Retinol binding protein 3 interstitial; Retinol-binding protein 3; RP66
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

IRBP shuttles 11-cis and all trans retinoids between the retinol isomerase in the pigment epithelium and the visual pigments in the photoreceptor cells of the retina.
基因功能參考文獻：
1. this report is the first to describe the retinal dystrophy in children caused by homozygous nonsense RBP3 mutations, highlighting the requirement for IRBP in normal eye development and visual function. PMID: 25766589
2. CMPK1 and RBP3 are associated with corneal curvature in Asian populations. PMID: 24963161
3. We found that most patients with macular telangiectasia-2 possess retinal autoantibodies, the most prevalent of which were directed against AGL, RBP3, and CK-B. PMID: 23882694
4. Secretory defect and cytotoxicity: the potential disease mechanisms for the retinitis pigmentosa (RP)-associated interphotoreceptor retinoid-binding protein (IRBP). PMID: 23486466
5. The mouse retina promotes cone dark adaptation eightfold faster than the retinal pigment epithelium. However, complete cone recovery requires both visual cycles. PMID: 21613504
6. Underproduction of IRBP is an early event in the human diabetic retina and is associated with retinal neurodegeneration. PMID: 19823802
7. studies suggest that IRBP and S-Ag can initiate innate and, in sensitive individuals, adaptive immune response by attracting iDCs and T and B cells expressing CXCR3 and CXCR5 PMID: 15713799
8. analysis of IRBP proteolysis is useful as a biomarker for uveitis PMID: 18266969
9. Mutations in RBP3 are an infrequent cause of autosomal recessive retinitis pigmentosa. PMID: 19074801
10. In interphotoreceptor retinoid-binding protein transgenic mice cone dysfunction appears to be caused by abnormal trafficking of cone opsins due to impaired delivery of all-transretinaldehyde chromophore without IRBP. PMID: 19193895
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相關疾病：

Retinitis pigmentosa 66 (RP66)
亞細胞定位：

Secreted, extracellular space, extracellular matrix, interphotoreceptor matrix. Note=Interphotoreceptor matrix that permeates the space between the retina and the contiguous layer of pigment epithelium cells.
蛋白家族：

Peptidase S41A family
數據庫鏈接：

HGNC: 9921

OMIM: 180290

KEGG: hsa:5949

STRING: 9606.ENSP00000224600

UniGene: Hs.591928