Recombinant Human Proline-serine-threonine phosphatase-interacting protein 1 (PSTPIP1)

中文名稱：

人PSTPIP1重組蛋白
貨號：

CSB-YP018944HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人PSTPIP1重組蛋白
貨號：

CSB-EP018944HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人PSTPIP1重組蛋白
貨號：

CSB-EP018944HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人PSTPIP1重組蛋白
貨號：

CSB-BP018944HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人PSTPIP1重組蛋白
貨號：

CSB-MP018944HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

PSTPIP1
Uniprot No.：

O43586
別名：

CD2 antigen binding protein 1; CD2 binding protein 1; CD2 cytoplasmic tail binding protein; CD2-binding protein 1; CD2BP1; CD2BP1L; CD2BP1S; H PIP; H-PIP; HPIP; PAPAS; PEST phosphatase interacting protein 1; PEST phosphatase-interacting protein 1; PPIP1_HUMAN; Proline serine threonine phosphatase interacting protein 1; Proline-serine-threonine phosphatase-interacting protein 1; PSTPIP; Pstpip1
種屬：

Homo sapiens (Human)
蛋白長度：

Full length protein
表達區域：

1-416
氨基酸序列

MMPQLQFKDA FWCRDFTAHT GYEVLLQRLL DGRKMCKDME ELLRQRAQAE ERYGKELVQI ARKAGGQTEI NSLRASFDSL KQQMENVGSS HIQLALTLRE ELRSLEEFRE RQKEQRKKYE AVMDRVQKSK LSLYKKAMES KKTYEQKCRD ADDAEQAFER ISANGHQKQV EKSQNKARQC KDSATEAERV YRQSIAQLEK VRAEWEQEHR TTCEAFQLQE FDRLTILRNA LWVHSNQLSM QCVKDDELYE EVRLTLEGCS IDADIDSFIQ AKSTGTEPPA PVPYQNYYDR EVTPLTSSPG IQPSCGMIKR FSGLLHGSPK TTSLAASAAS TETLTPTPER NEGVYTAIAV QEIQGNPASP AQEYRALYDY TAQNPDELDL SAGDILEVIL EGEDGWWTVE RNGQRGFVPG SYLEKL
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Involved in regulation of the actin cytoskeleton. May regulate WAS actin-bundling activity. Bridges the interaction between ABL1 and PTPN18 leading to ABL1 dephosphorylation. May play a role as a scaffold protein between PTPN12 and WAS and allow PTPN12 to dephosphorylate WAS. Has the potential to physically couple CD2 and CD2AP to WAS. Acts downstream of CD2 and CD2AP to recruit WAS to the T-cell:APC contact site so as to promote the actin polymerization required for synapse induction during T-cell activation. Down-regulates CD2-stimulated adhesion through the coupling of PTPN12 to CD2. Also has a role in innate immunity and the inflammatory response. Recruited to inflammasomes by MEFV. Induces formation of pyroptosomes, large supramolecular structures composed of oligomerized PYCARD dimers which form prior to inflammatory apoptosis. Binding to MEFV allows MEFV to bind to PYCARD and facilitates pyroptosome formation. Regulates endocytosis and cell migration in neutrophils.
基因功能參考文獻：
1. We identified HPIP protein expression as a novel independent poor prognostic indicator in cervical cancer PMID: 30033330
2. Case Report: classical pyogenic arthritis, pyoderma gangrenosum, and acne (PAPA) syndrome with E250K mutation of PSTPIP1. PMID: 28628471
3. HPIP expression is associated with high-grade ovarian tumors. PMID: 28039608
4. we demonstrated that HPIP silencing suppressed TGF-beta1-induced EMT in lung cancer cells by inhibiting Smad2 activation. PMID: 28075456
5. our study demonstrated that knockdown of HPIP significantly inhibits the proliferation and migration/invasion of HNSCC cells by suppressing the PI3K/Akt signaling pathway. PMID: 27458096
6. these structural variations in CD2BP1 gene due to the mutations could be one of the strongest reasons to demonstrate the involvement of these gene variations in the patients with rheumatoid arthritis. PMID: 27184502
7. PSTPIP1 was found to interact with pyrin at the leading edge during cell migration. PMID: 26179737
8. genetic polymorphism is associated with hyperzincemia and hypercalprotectinemia PMID: 26025129
9. Molecular interactions between HPIP and FAK, and HPIP and calpain2 regulate cell adhesion and migration through modulation of focal adhesion dynamics. PMID: 25486428
10. Case Report: missense mutation in PSTPIP1, the gene responsible for PAPA syndrome. PMID: 24960411
11. we have shown that PSTPIP1 regulates T-cell activation upon CD3 and CD28 stimulation, independently of CD2 costimulation. PSTPIP1 acts downstream of proximal TCR signaling, inhibiting several transcription factors. PMID: 25040622
12. PSTPIP1 has a role in the pathogenesis of pyoderma gangrenosum through filopodia formation resulting in extracellular matrix degradation PMID: 24421327
13. novel mutaations found in PSTPIP1 gene in patients with pyoderma gangrenosum PMID: 21790734
14. non-mutated gene and pyoderma gangrenosum in IBD unresponsive to anakinra treatment PMID: 21438098
15. The CCTG repeat in the PSTPIP1 promoter may play a role in the pathogenesis of aseptic abscess syndrome and Crohn's disease. PMID: 19731031
16. CD2BP1-mediated biochemical pathway(s) may function in common inflammatory disorders with apparent etiological overlap, such as rheumatoid arthritis and inflammatory bowel disease PMID: 11971877
17. PSTPIP1/CD2BP1 protein binds to pyrin PMID: 14595024
18. the intracellular Fas ligand (FasL) domain binding to the adaptor protein PSTPIP results in a cytoplasmic localization of FasL PMID: 16204241
19. CD2BP1 directly and negatively impacts T cell activation via isolated CD2 antigen triggering or T-cell receptor stimulation dependent on coordinate CD2 engagement. PMID: 16670297
20. PSTPIP1 mutants require pyrin to induce formation of ASC pyroptosome, a molecular platform that recruits and activates caspase-1. PMID: 17964261
21. PSTPIP1 is a novel component of the leukocyte uropod that regulates endocytosis and cell migration PMID: 18480402
22. These findings support the use of monogenic loci as candidates for investigating the genetic component of complex disease and provide preliminary evidence of association between SNPs in autoinflammatory genes and psoriatic JIA. PMID: 18576390
23. demonstrate that pyrin can recruit PSTPIP1 into aggregations (specks) of ASC, another pyrin binding protein. ASC specks are associated with inflammasome activity PMID: 19584923
24. PAPA syndrome occurs without identifiable mutation in CD2BB1 PMID: 19700023
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相關疾?。?/div>
PAPA syndrome (PAPAS)
亞細胞定位：

Cytoplasm. Cell membrane; Peripheral membrane protein. Cell projection, uropodium. Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Cell projection, lamellipodium. Cleavage furrow.
組織特異性：

Highly expressed in the peripheral blood leukocytes, granulocytes and monocytes, namely in T-cells and natural killer cells, and in spleen. Weakly expressed in the thymus, small intestine, lung and placenta.
數據庫鏈接：

HGNC: 9580

OMIM: 604416

KEGG: hsa:9051

STRING: 9606.ENSP00000452746

UniGene: Hs.129758