Recombinant Human Pleckstrin-2 (PLEK2)

中文名稱：

人PLEK2重組蛋白
貨號(hào)：

CSB-YP868361HU
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

人PLEK2重組蛋白
貨號(hào)：

CSB-EP868361HU
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
其他：

中文名稱：

人PLEK2重組蛋白
貨號(hào)：

CSB-EP868361HU-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人PLEK2重組蛋白
貨號(hào)：

CSB-BP868361HU
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

人PLEK2重組蛋白
貨號(hào)：

CSB-MP868361HU
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

PLEK2
Uniprot No.：

Q9NYT0
別名：

Pleckstrin 2 (mouse) homolog; Pleckstrin 2; Pleckstrin-2; PLEK 2; PLEK2; PLEK2_HUMAN
種屬：

Homo sapiens (Human)
蛋白長度：

full length protein
表達(dá)區(qū)域：

1-353
氨基酸序列

MEDGVLKEGF LVKRGHIVHN WKARWFILRQ NTLVYYKLEG GRRVTPPKGR ILLDGCTITC PCLEYENRPL LIKLKTQTST EYFLEACSRE ERDAWAFEIT GAIHAGQPGK VQQLHSLRNS FKLPPHISLH RIVDKMHDSN TGIRSSPNME QGSTYKKTFL GSSLVDWLIS NSFTASRLEA VTLASMLMEE NFLRPVGVRS MGAIRSGDLA EQFLDDSTAL YTFAESYKKK ISPKEEISLS TVELSGTVVK QGYLAKQGHK RKNWKVRRFV LRKDPAFLHY YDPSKEENRP VGGFSLRGSL VSALEDNGVP TGVKGNVQGN LFKVITKDDT HYYIQASSKA ERAEWIEAIK KLT
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

May help orchestrate cytoskeletal arrangement. Contribute to lamellipodia formation.
基因功能參考文獻(xiàn)：
1. expression of PLEK2, the strongest gene to classify melanoma patients, in CD45(-) subsets illustrates the importance of analyzing whole blood cells for biomarker studies PMID: 21698244
2. Pleckstrin 2 was cloned; its mRNA is widely expressed in a variety of cell lines. PMID: 15865208
3. pleckstrin-2 uses its modular domains to bind to membrane-associated phosphatidylinositols generated by PI3K, whereby it coordinates with the actin cytoskeleton in lymphocyte spreading and immune synapse formation. PMID: 17008542
4. These results suggest that PLEK2 is involved in actin rearrangement in a PI 3-kinase dependent manner. PMID: 17658464
亞細(xì)胞定位：

Cell projection, lamellipodium membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton.
數(shù)據(jù)庫鏈接：

HGNC: 19238

OMIM: 608007

KEGG: hsa:26499

STRING: 9606.ENSP00000216446

UniGene: Hs.170473