Recombinant Human PR domain zinc finger protein 1 (PRDM1), partial
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中文名稱：人PRDM1重組蛋白
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貨號：CSB-EP018638HU-B
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說明書：
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規格：
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來源：E.coli
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共軛：Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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其他：
產品詳情
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純度：>85% (SDS-PAGE)
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基因名：PRDM1
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Uniprot No.：
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別名：B Lymphocyte Induced Maturation Protein 1; Beta interferon gene positive regulatory domain I binding factor; Beta-interferon gene positive regulatory domain I-binding factor; BLIMP-1; BLIMP1; Positive Regulatory Domain I Binding Factor 1; Positive regulatory domain I-binding factor 1; PR Domain Containing 1; PR domain containing 1 with ZNF domain; PR domain containing 1 with ZNF domain isoform 2; PR domain containing protein 1; PR domain zinc finger protein 1; PR domain-containing protein 1; PRDI BF1; PRDI binding factor 1; PRDI-BF1; PRDI-binding factor 1; PRDM 1; Prdm1; PRDM1_HUMAN
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種屬：Homo sapiens (Human)
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蛋白長度：Partial
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蛋白標簽：Tag?type?will?be?determined?during?the?manufacturing?process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially. -
產品提供形式：Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 668
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand. -
復溶：We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
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儲存條件：Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
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保質期：The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. -
貨期：Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
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注意事項：Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Datasheet ：Please contact us to get it.
產品評價
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靶點詳情
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功能：Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells. Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions.
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基因功能參考文獻：
- The authors herein prove, for the first time, that the transcriptional repressor Blimp1 is a novel mediator of p130Cas/ErbB2-mediated invasiveness. Indeed, high Blimp1 expression levels are detected in invasive p130Cas/ErbB2 cells and correlate with metastatic status in human breast cancer patients. PMID: 28442738
- Studied role of PR/SET domain 1 (PRDM1) protein in colon cancer; found that PRDM1beta acts as a tumor-suppressor gene in colon tumor organoids, probably by acting downstream of p53. The study also shows It modifies the expression of stem cell related genes, inhibits colon epithelial cell proliferation, and is associated with good survival in colon cancer patients. PMID: 29760071
- Data found that intratumoral hypoxia, which is an inevitable feature of advanced human pancreatic ductal adenocarcinoma, induces the expression of the pro-metastatic transcription factor Blimp1. The co-option of this master regulatory transcription factor is required for metastatic ability, and the molecular output of Blimp1 expression is the modulation of discrete hypoxia-induced gene expression programs. PMID: 28790031
- Blimp1, Foxp1 and pStat3 are expressed in extranodal diffuse large B-cell lymphomas PMID: 27924626
- In conclusion, aberrant coexpression of MYC and PRDM1/Blimp1alpha owing to genetic changes is responsible for the phenotype of plasmablastic lymphoma cases. PMID: 27687004
- Blimp-1 binds to the promoters of PD-1 and TIGIT and positively regulates their expression in patients with acute myeloid leukemia. PMID: 28629373
- the promoter hypermethylation of PRDM1 harbored a predominant role in the downregulation of PRDM1 expression, significantly affecting the biological behavior of tumor cells in EN-NK/T-NT. PMID: 27704586
- Blimp-1 suppresses the transcription of CUL4A, resulting in the maintenance of the expression of Aiolos and Ikaros. PMID: 26823144
- HSP70-Hrd1 axis represents a potential therapeutic target for restoring the oncorepressor activity of unstable lymphoma-associated Blimp-1 mutants. PMID: 28842558
- SOX2 repression in TCam-2 cells can be abrogated by recruitment of the constitutively expressed H3K27 demethylase UTX to the SOX2 promoter through retinoid signaling, leading to expression of neuronal and other lineage genes. SOX17 has been shown to initiate human PGC specification, with its target PRDM1 suppressing mesendodermal genes PMID: 27132888
- The interaction between c-Maf and RORgammat, and Blimp-1. PMID: 28300844
- these results provide novel clinical and biological insight into the tumor-suppressive role of PRDM1/BLIMP-1 in ABC-DLBCL patients and suggest that loss of PRDM1/BLIMP-1 function contributes to the overall poor prognosis of ABC-DLBCL patients. PMID: 27568520
- PRDM1 was identified as a susceptibility gene for systemic sclerosis. PMID: 28314753
- Data indicate that BTG2, MAP3K11, RPS6KA1 and PRDM1 as putative targets of microRNA miR-125b. PMID: 27613090
- we identified MIR155HG and TERC to be transcriptionally downregulated by PRDM1 in two PRDM1-null NK-cell lines when it is ectopically expressed. These findings suggest that ZFAS1 and other dysregulated long non-coding RNAs may be involved in natural killer/T-cell lymphoma pathobiology through regulation of cancer-related genes, and loss-of-PRDM1 expression in natural killer/T-cell lymphomas tumorigenesis PMID: 28468592
- identified the Prdm1 gene encoding the B lymphocyte-induced maturation protein 1 as a crucial negative regulator of human TH17 cell differentiation PMID: 26976045
- B cell receptor signaling component, SYK, caused PAX5 tyrosine phosphorylation in vitro and in cells. Transcriptional repression on the BLIMP1 promoter by PAX5 was attenuated by this phosphorylation. PMID: 27181361
- Depletion of PRDM1 in lung cancer cells promotes cellular invasion and anoikis resistance in vitro and lung metastasis in vivo. PMID: 28378641
- The PRDM1 expression appeared to play an essential role in Warthin tumour pathogenesis. PMID: 25280345
- Blimp-1 regulates the transcription of CS1 gene in NK and B cell lines from multiple myeloma and diffuse large B cell lymphoma patients. PMID: 26310579
- Antineoplastic effects of liposomal short interfering RNA treatment targeting BLIMP1/PRDM1 in primary effusion lymphoma. PMID: 26206802
- The interaction between EBV-miR-BHRF1-2 and PRDM1 may be one of the mechanisms by which EBV-miRBHRF1-2 promotes Epstein-Barr virus lymphomagenesis. PMID: 26530011
- heterozygous deletion of 6q21 and/or PRDM1 was frequently detected in extranodal NK/T cell lymphoma, nasal type and correlated with downregulation of PRDM1. PMID: 26221594
- KLF4, together with BLIMP1, plays a critical role in mediating lytic Epstein-Barr virus reactivation in epithelial cells. PMID: 26431332
- aberrant methylation silencing of PRDM1alpha and hypomethylation activation of PRDM1beta are frequent events in DLBCL. PMID: 25487076
- Our findings suggest a previously unrecognized role of PRDM1 and human parvovirus B19 in the pathogenesis of Hashimoto thyroiditis PMID: 26475096
- Blimp1-deficient effector T cells fail to produce IL-10, and deficiency in Tr-1 cell function leads to uncontrolled Th17 cell-driven CNS pathology without the need to stabilize the Th17 phenotype with IL-23 PMID: 24796719
- Positional mapping of PRKD1, NRP1 and PRDM1 as novel candidate disease genes in truncus arteriosus PMID: 25713110
- Blimp-1 expression in dendritic cells can alter an innate inflammatory response by modulating the activation of myeloid cells PMID: 25826676
- Data show that vascular endothelial growth factor (VEGF) upregulates the transcription repressor PRD1-BF1 protein in endothelial cells. PMID: 26212250
- study gives no definite evidence for a pathogenic genetic link of periodontitis and RA but suggests IRF5 and PRDM1 as shared susceptibility factors. PMID: 25263394
- level of Blimp-1 mRNA in the monocytes from patients with active tuberculosis and latent tuberculosis infection subjects was down-regulated PMID: 26146066
- results expand the spectrum of lymphoid malignancies in which PRDM1 may have a tumor suppressor role and identify an epigenetic event that likely contributes to the pathogenesis of BL. PMID: 25382611
- peritoneal fluid mRNA level significantly elevated in endometriosis PMID: 26054109
- the transcriptional repressor, Blimp-1, is an intrinsic factor that predisposes CD4(+) memory T cells to latent HIV-1 infection. PMID: 25710909
- our results demonstrate that PRDM1 serves as a molecular switch to modulate the divergence of neural or germline fates through repression of SOX2 during human development. PMID: 24527393
- These data suggest that Blimp-1 might be involved in controlling the HIV reservoirs in the key central-memory T-cell subset. PMID: 24804861
- Authors conclude that BLIMP1 expression is both necessary and sufficient to induce Epstein-Barr virus lytic replication in many (possibly all) latently infected epithelial-cell types, but in only a subset of B-cell types. PMID: 25410866
- Single nucleotide polymorphism in PRDM1 gene is associated with Hodgkin disease therapy induced second malignancy. PMID: 24306881
- miR-23a and miR-125b, proved to be negatively associated with up-modulation of Blimp-1 occurring during IFN-alpha-driven dendritic cell differentiation. PMID: 23977359
- The failure of chronic lymphocytic leukemia cells to express or induce PRDM1 correlates with anergy. PMID: 24637363
- Downregulation of the tumour suppressor PRDM1 in extranodal NK/T-cell lymphoma, nasal type, is mediated by miR-223. PMID: 24438193
- Data indicate that B lymphocyte induced maturation protein 1 (Blimp1) mRNA expression level was 2.1 times greater in the SLE group as compared to the control group. PMID: 23911415
- In vitro and in vivo experiments showed that that PRDM1 is a tumor suppressor gene in anaplastic large T-cell lymphoma models, likely acting as an antiapoptotic agent. PMID: 24004669
- Two missense SNPs, chr6:106659789 (Ser354Asn) and chr6:106660076 (Leu450Phe) at PRDM1 on chromosome 6q21, were significantly associated with Crohn's disease and ulcerative colitis. PMID: 23624108
- Blimp-1 levels are translationally regulated by microRNA-9 (miR-9). PMID: 23129528
- found that PRDM1 was a direct target of miR-30a-5p, and PRDM1 dysfunction was attributable to miR-30a-5p-mediated repression PMID: 23348703
- A parent-of-origin effect in inflammatory bowel diseases was observed for single nucleotide polymorphisms in IL12B, PRDM1, and IL10. PMID: 23028907
- data provide evidence that abundance of Blimp-1, and consequently the secretion of proinflammatory cytokines such as IL-2, is regulated in 2 ways: (i)transcriptional regulation by activation of CD4( )T cells and (ii) posttranscriptional regulation by enhanced miR-9 expression PMID: 22585398
- loss of BLIMP1alpha as an important step in the pathogenesis of the Epstein-Barr virus (EBV) associated B cell lymphomas PMID: 22580854
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亞細胞定位：Nucleus. Cytoplasm.
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蛋白家族：Class V-like SAM-binding methyltransferase superfamily
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