Recombinant Human Noelin-2 (OLFM2)

中文名稱：

人OLFM2重組蛋白
貨號：

CSB-YP016321HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人OLFM2重組蛋白
貨號：

CSB-EP016321HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人OLFM2重組蛋白
貨號：

CSB-EP016321HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人OLFM2重組蛋白
貨號：

CSB-BP016321HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人OLFM2重組蛋白
貨號：

CSB-MP016321HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

OLFM2
Uniprot No.：

O95897
別名：

Neuronal olfactomedin related ER localized protein 2; NOE2; NOE2_HUMAN; Noelin 2; Noelin-2; NOELIN2; NOELIN2 V1; Olfactomedin 2; Olfactomedin-2; OlfC; Olfm2
種屬：

Homo sapiens (Human)
蛋白長度：

Full length protein
表達區域：

21-454
氨基酸序列

QTLFQNPEEG WQLYTSAQAP DGKCICTAVI PAQSTCSRDG RSRELRQLME KVQNVSQSME VLELRTYRDL QYVRGMETLM RSLDARLRAA DGSLSAKSFQ ELKDRMTELL PLSSVLEQYK ADTRTIVRLR EEVRNLSGSL AAIQEEMGAY GYEDLQQRVM ALEARLHACA QKLGCGKLTG VSNPITVRAM GSRFGSWMTD TMAPSADSRV WYMDGYYKGR RVLEFRTLGD FIKGQNFIQH LLPQPWAGTG HVVYNGSLFY NKYQSNVVVK YHFRSRSVLV QRSLPGAGYN NTFPYSWGGF SDMDFMVDES GLWAVYTTNQ NAGNIVVSRL DPHTLEVMRS WDTGYPKRSA GEAFMICGVL YVTNSHLAGA KVYFAYFTNT SSYEYTDVPF HNQYSHISML DYNPRERALY TWNNGHQVLY NVTLFHVIST SGDP
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Involved in transforming growth factor beta (TGF-beta)-induced smooth muscle differentiation. TGF-beta induces expression and translocation of OLFM2 to the nucleus where it binds to SRF, causing its dissociation from the transcriptional repressor HEY2/HERP1 and facilitating binding of SRF to target genes. Plays a role in AMPAR complex organization. Is a regulator of vascular smooth-muscle cell (SMC) phenotypic switching, that acts by promoting RUNX2 and inhibiting MYOCD binding to SRF. SMC phenotypic switching is the process through which vascular SMCs undergo transition between a quiescent contractile phenotype and a proliferative synthetic phenotype in response to pathological stimuli. SMC phenotypic plasticity is essential for vascular development and remodeling.
基因功能參考文獻：
1. plasma OLFM2 is a potential biomarker for restenosis and may be a novel target for the treatment of restenosis. PMID: 29553861
2. Our study indicates that OLFM2 is likely to be important in mammalian eye development and disease and should be considered as a gene for human ocular anomalies. PMID: 27844144
3. Olfm2 physically interacts with serum response factor (SRF) without affecting the SRF-myocardin interaction. PMID: 25298399
4. The Arg144Gln mutation in OLFM2 is a possible disease-causing mutation in Japanese patients with OAG. Common polymorphisms in OLFM2 and OPTN may interactively contribute to the development of OAG, indicating a polygenic etiology. PMID: 17122126
亞細胞定位：

Secreted. Cell junction, synapse. Membrane. Nucleus. Cytoplasm.
組織特異性：

Expressed in aortic smooth muscle (at protein level). In the fetus, expressed in the brain and ocular tissues including lens vesicle and optic cup.
數據庫鏈接：

HGNC: 17189

OMIM: 617492

KEGG: hsa:93145

STRING: 9606.ENSP00000264833

UniGene: Hs.169743