Recombinant Human MutS protein homolog 5 (MSH5), partial

中文名稱：

人MSH5重組蛋白
貨號：

CSB-YP015031HU
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

人MSH5重組蛋白
貨號：

CSB-EP015031HU
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
其他：

中文名稱：

人MSH5重組蛋白
貨號：

CSB-EP015031HU-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人MSH5重組蛋白
貨號：

CSB-BP015031HU
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

人MSH5重組蛋白
貨號：

CSB-MP015031HU
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

MSH5
Uniprot No.：

O43196
別名：

DKFZp434C1615; G7; hMSH5; MGC2939; MSH 5; MSH5; MSH5_HUMAN; mutS (E. coli) homolog 5 ; mutS homolog 5 ; mutS homolog 5 (E. coli); MutS protein homolog 5; MutSH5; NG23; OTTHUMP00000029187; OTTHUMP00000029188
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Involved in DNA mismatch repair and meiotic recombination processes. Facilitates crossovers between homologs during meiosis.
基因功能參考文獻(xiàn)：
1. From sanger sequencing of MSH5 in 200 sporadic POI patients, we identified three heterozygous mutations . Considering the heterozygous p.D487Y carrier in the POI pedigree was fertile, the causality of the three heterozygous mutations in POI need more evidence PMID: 28175301
2. our data point to the existence of a functional interplay between hMSH5 and FANCJ in double-strand break repair induced by replication stress. PMID: 26055704
3. the roles of hMSH5 variants in the processes of DNA damage response and repair PMID: 24023853
4. Authors show that MSH5 (MutSHomolog 5) is localized into the mitochondria of germ and somatic cells. PMID: 22917773
5. Study has suggested a role for hMSH5 in the processing of cisplatin-induced DSBs, and silencing of hMSH5 may provide a new means to improve the therapeutic efficacy of cisplatin. PMID: 22401567
6. The presence of the MSH5 85F allele marks the subgroup of DRB1*0102 haplotypes carrying susceptibility for selective IgA deficiency. MSH5 polymorphisms per se are not predisposing factors. PMID: 20542071
7. hMSH5 possesses a CRM1-dependent nuclear export signal and a nuclear localization signal that participates to its nuclear targeting. PMID: 20185565
8. There is an association of polymorphism C85T in MSH5 or C2531T in MLH3 with male infertility, specifically azoospermia or severe oligozoospermia, and interaction between these MSH5 and MLH3 polymorphisms increased the risk of developing male infertility PMID: 19808033
9. A review of the properties and functional roles of MSH5. PMID: 17127347
10. These findings suggest that Msh4/5 heterodimers contribute to class switch recombination. PMID: 17409188
11. Data show that MSH5 mutations may be one explanation for premature ovarian failure. PMID: 18166824
12. Biochemical identification of the proteins with which it interacted showed that SMCY formed a distinct complex with MSH5, a critical meiosis-regulatory protein in the human testicular germ cell line, NEC8. PMID: 18459961
13. this study implicates a role for hMSH5 in DNA damage response involving c-Abl and p73, and suggests that mutations impairing this process could significantly affect normal cellular responses to anti-cancer treatments. PMID: 19442657
14. occurrence of an unusual TG 3' splice site in intron 6 PMID: 17672918
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相關(guān)疾病：

Premature ovarian failure 13 (POF13)
蛋白家族：

DNA mismatch repair MutS family
組織特異性：

Widely expressed, with high levels in testis and ovary, including granulosa cells. Also expressed in fetal ovary and adrenal gland.
數(shù)據(jù)庫鏈接：

HGNC: 7328

OMIM: 603382

KEGG: hsa:4439

STRING: 9606.ENSP00000364855

UniGene: Hs.647011