Recombinant Human Multimerin-1 (MMRN1), partial

中文名稱：

人MMRN1重組蛋白
貨號：

CSB-YP622645HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人MMRN1重組蛋白
貨號：

CSB-EP622645HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人MMRN1重組蛋白
貨號：

CSB-EP622645HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人MMRN1重組蛋白
貨號：

CSB-BP622645HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人MMRN1重組蛋白
貨號：

CSB-MP622645HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

MMRN1
Uniprot No.：

Q13201
別名：

155 kDa platelet multimerin; ECM; Elastin microfibril interface located protein 4; Elastin microfibril interfacer 4; EMILIN 4; EMILIN-4; EMILIN4; Endothelial cell multimerin 1; Endothelial cell multimerin; Glycoprotein Ia*; GlycoproteinIa*; GPIa*; MMRN 1; MMRN; MMRN1; MMRN1_HUMAN; Multimerin 1; Multimerin1; p-155; p155
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Carrier protein for platelet (but not plasma) factor V/Va. Plays a role in the storage and stabilization of factor V in platelets. Upon release following platelet activation, may limit platelet and plasma factor Va-dependent thrombin generation. Ligand for integrin alpha-IIb/beta-3 and integrin alpha-V/beta-3 on activated platelets, and may function as an extracellular matrix or adhesive protein.
基因功能參考文獻：
1. VWF binding to MMRN1 was enhanced by shear exposure and ristocetin, and required VWF A1A2A3 region, specifically the A1 and A3 domains. PMID: 27052467
2. Lower levels of anti-elastin are related to CAD [ coronary artery disease ] PMID: 26446635
3. our studies identify MMRN1 expression as a novel biomarker that may refine acute myelogenous leukemia risk stratification. PMID: 25825478
4. multimerin 1 has a role in delivering and localizing factor V onto platelets prior to prothrombinase assembly PMID: 15452129
5. disulfide-linked complexes of multimerin and factor V in platelets could be important for modulating the function of platelet factor V and its delivery onto activated platelets PMID: 15583744
6. MMRN1 is a ligand for alphaIIbbeta3 and alphavbeta3 PMID: 16363244
7. The MMRN1 binding site was located in Factor V. PMID: 18452976
8. Multimerin 1 binds factor V and activated factor V with high affinity and inhibits thrombin generation. PMID: 19132231
9. MMRN1 supported the adhesion of activated, but not resting, washed platelets over a wide range of shear rates PMID: 19175495
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相關疾病：

Deficiency in multimerin-1 due to proteolytic degradation within the platelet alpha granules is associated with an autosomal dominant bleeding disorder (factor V Quebec).
亞細胞定位：

Secreted.
組織特異性：

Synthesized by endothelial cells and megakaryocytes. Stored in platelet alpha granules and endothelial cell Weibel-Palade bodies, following activation of these cells, it is released and attached to megakaryocytes, platelets, endothelium and subendothelium
數據庫鏈接：

HGNC: 7178

OMIM: 601456

KEGG: hsa:22915

STRING: 9606.ENSP00000264790

UniGene: Hs.268107