Recombinant Human Mitochondrial uncoupling protein 4 (SLC25A27), partial

中文名稱：

人SLC25A27重組蛋白
貨號：

CSB-YP021496HU1
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人SLC25A27重組蛋白
貨號：

CSB-EP021496HU1
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人SLC25A27重組蛋白
貨號：

CSB-EP021496HU1-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人SLC25A27重組蛋白
貨號：

CSB-BP021496HU1
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人SLC25A27重組蛋白
貨號：

CSB-MP021496HU1
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

SLC25A27
Uniprot No.：

O95847
別名：

SLC25A27; UCP4; UNQ772/PRO1566; Mitochondrial uncoupling protein 4; UCP 4; Solute carrier family 25 member 27
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat. May play a role in thermoregulatory heat production and metabolism in brain.
基因功能參考文獻：
1. This study found that the variability of UCP4 does affect the individual susceptibility to Late-Onset Alzheimer's Disease. PMID: 26923023
2. UCP4 mRNA of cartilage tissues was decreased in osteoarthritis patients, which was negatively correlated with synovial fluid (SF) leptin concentration. PMID: 26934480
3. UCP4 is a target effector gene of the NF-kappaB c-Rel prosurvival pathway to mitigate the effects of oxidative stress. PMID: 22580300
4. Neuronal UCP4 exhibits transmembrane chloride transport activity. PMID: 22524567
5. Findings show how UCP4 overexpression increases ATP synthesis by specifically interacting with Complex II. PMID: 22427795
6. UCP4 expression correlated with lymph node metastases, positive estrogen/progesterone receptor expression, and positivity for p53 and Ki-67 in breast carcinomas. PMID: 21621926
7. A homozygous genetic variant of mitochondrial uncoupling protein 4 affects the occurrence of leukoaraiosis.( PMID: 20545631
8. the association found between the ultra-resistant schizophrenia group and the UCP4 haplotype is noteworthy as it may influence treatment outcome in schizophrenia. PMID: 21332312
9. has a significant role in NF-kappaB-mediated prosurvival signaling and cell protection against neurotoxins PMID: 20385226
10. Results suggest that mitochondrial UCP4 mediates an adaptive shift in energy metabolism and increases the resistance of neurons to metabolic and oxidative stress. PMID: 16775390
11. The stabilization of Ca(2+) homeostasis and preservation of mitochondrial function by UCP4 was correlated with reduced mitochondrial reactive oxygen species generation and oxidative stress. PMID: 17035241
12. overexpression increases neural cell survival by inducing oxidative phosphorylation, preserving ATP synthesis and mitochondrial membrane potential, and reducing oxidative stress. PMID: 19150400
13. Data describe how variants of mitochondrial uncoupling protein 4 (mUCP4) may contibute to development of multiple sclerosis, since mUCP4 is presumed to be of importance in regulation of the mitochondrial membrane potential and cellular energy metabolism. PMID: 19536655
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亞細胞定位：

Mitochondrion inner membrane; Multi-pass membrane protein.
蛋白家族：

Mitochondrial carrier (TC 2.A.29) family
組織特異性：

Found in adult and fetal brain. Present in most of the brain tissues, with low levels in spinal chord, corpus callosum and substantia nigra.
數據庫鏈接：

HGNC: 21065

OMIM: 613725

KEGG: hsa:9481

STRING: 9606.ENSP00000360398

UniGene: Hs.40510