Recombinant Human Max-binding protein MNT (MNT)

中文名稱：

人MNT重組蛋白
貨號：

CSB-YP857452HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人MNT重組蛋白
貨號：

CSB-EP857452HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人MNT重組蛋白
貨號：

CSB-EP857452HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人MNT重組蛋白
貨號：

CSB-BP857452HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人MNT重組蛋白
貨號：

CSB-MP857452HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

MNT
Uniprot No.：

Q99583
別名：

bHLHd3; Class D basic helix-loop-helix protein 3; MAD6; MAX binding protein; Max binding protein MNT; MAX network transcriptional repressor; Max-binding protein MNT; Mnt; MNT_HUMAN; MXD6; Myc antagonist MNT; Protein ROX; ROX
種屬：

Homo sapiens (Human)
蛋白長度：

Full Length of Mature Protein
表達區域：

2-582
氨基酸序列

SIETLLEAA RFLEWQAQQQ QRAREEQERL RLEQEREQEQ KKANSLARLA HTLPVEEPRM EAPPLPLSPP APPPAPPPPL ATPAPLTVIP IPVVTNSPQP LPPPPPLPAA AQPLPLAPRQ PALVGAPGLS IKEPAPLPSR PQVPTPAPLL PDSKATIPPN GSPKPLQPLP TPVLTIAPHP GVQPQLAPQQ PPPPTLGTLK LAPAEEVKSS EQKKRPGGIG TREVHNKLEK NRRAHLKECF ETLKRNIPNV DDKKTSNLSV LRTALRYIQS LKRKEKEYEH EMERLAREKI ATQQRLAELK HELSQWMDVL EIDRVLRQTG QPEDDQASTS TASEGEDNID EDMEEDRAGL GPPKLSHRPQ PELLKSTLPP PSTTPAPLPP HPHPHPHSVA LPPAHLPVQQ QQPQQKTPLP APPPPPAAPA QTLVPAPAHL VATAGGGSTV IAHTATTHAS VIQTVNHVLQ GPGGKHIAHI APSAPSPAVQ LAPATPPIGH ITVHPATLNH VAHLGSQLPL YPQPVAVSHI AHTLSHQQVN GTAGLGPPAT VMAKPAVGAQ VVHHPQLVGQ TVLNPVTMVT MPSFPVSTLK LA
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Binds DNA as a heterodimer with MAX and represses transcription. Binds to the canonical E box sequence 5'-CACGTG-3' and, with higher affinity, to 5'-CACGCG-3'.
基因功能參考文獻：
1. In vitro, uremia induced dysregulation of DNA methylation in differentiating monocytes, which affected several transcription regulators important for monocyte differentiation (e.g., FLT3, HDAC1, MNT) and led to enhanced generation of intermediate monocytes. PMID: 27018948
2. The data demonstrate that the balance between c-Myc and Mnt activity determines the transcriptional outcome of the hTERT promoter by modulation of the chromatin architecture. PMID: 23860446
3. The results suggest that MNT, via interaction with Nck1, inhibits hepatoma cell migration. PMID: 22964333
4. downregulation MYCN was reflected in a decreased MYCN/Max DNA-binding activity while the Mnt/Max binding did not change during differentiation PMID: 15258910
5. Serum stimulation of quiescent cells results in phosphorylation of Mnt and disruption of the critical Mnt-mSin3-HDAC1 interaction. This in turn leads to increased expression of the Myc/Mnt target gene cyclin D2. Review. PMID: 17419941
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亞細胞定位：

Nucleus.
數據庫鏈接：

HGNC: 7188

OMIM: 603039

KEGG: hsa:4335

STRING: 9606.ENSP00000174618

UniGene: Hs.626579