Recombinant Human Leucine-rich repeat protein 1 (LRR1)

中文名稱：

人LRR1重組蛋白
貨號：

CSB-YP836247HU
規格：
來源：

Yeast
其他：

中文名稱：

人LRR1重組蛋白
貨號：

CSB-EP836247HU
規格：
來源：

E.coli
其他：

中文名稱：

人LRR1重組蛋白
貨號：

CSB-EP836247HU-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人LRR1重組蛋白
貨號：

CSB-BP836247HU
規格：
來源：

Baculovirus
其他：

中文名稱：

人LRR1重組蛋白
貨號：

CSB-MP836247HU
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

LRR1
Uniprot No.：

Q96L50
別名：

4 1BB mediated signaling molecule; 4 1BBlrr ; 4-1BB-mediated-signaling molecule; 4-1BBlrr; Cyclophilin like 5; Leucine-rich repeat protein 1; LLR1_HUMAN; LRR 1; LRR repeat protein 1; LRR-1; LRR-repeat protein 1; LRR1; MGC20689; peptidylprolyl isomerase (cyclophilin) like 5; Peptidylprolyl isomerase like 5; Peptidylprolyl isomerase-like 5; PPIL5
種屬：

Homo sapiens (Human)
蛋白長度：

full length protein
表達區域：

1-414
氨基酸序列

MKLHCEVEVI SRHLPALGLR NRGKGVRAVL SLCQQTSRSQ PPVRAFLLIS TLKDKRGTRY ELRENIEQFF TKFVDEGKAT VRLKEPPVDI CLSKAISSSL KGFLSAMRLA HRGCNVDTPV STLTPVKTSE FENFKTKMVI TSKKDYPLSK NFPYSLEHLQ TSYCGLVRVD MRMLCLKSLR KLDLSHNHIK KLPATIGDLI HLQELNLNDN HLESFSVALC HSTLQKSLRS LDLSKNKIKA LPVQFCQLQE LKNLKLDDNE LIQFPCKIGQ LINLRFLSAA RNKLPFLPSE FRNLSLEYLD LFGNTFEQPK VLPVIKLQAP LTLLESSART ILHNRIPYGS HIIPFHLCQD LDTAKICVCG RFCLNSFIQG TTTMNLHSVA HTVVLVDNLG GTEAPIISYF CSLGCYVNSS DMLK
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

May negatively regulate the 4-1BB-mediated signaling cascades which result in the activation of NK-kappaB and JNK1. Probable substrate recognition subunit of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
基因功能參考文獻：
1. Results identify the CRL2(LRR-1) ubiquitin ligase as a conserved regulator of Cip/Kip CKIs that promotes the degradation of C. elegans CKI-1 and human p21. PMID: 21074724
組織特異性：

Ubiquitous. Maximal expression was seen in the heart and skeletal muscle and minimal expression seen in the kidney.
數據庫鏈接：

HGNC: 19742

OMIM: 609193

KEGG: hsa:122769

STRING: 9606.ENSP00000298288

UniGene: Hs.451090