Recombinant Human Krueppel-like factor 12 (KLF12)

中文名稱：

人KLF12重組蛋白
貨號：

CSB-YP897495HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人KLF12重組蛋白
貨號：

CSB-EP897495HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人KLF12重組蛋白
貨號：

CSB-EP897495HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人KLF12重組蛋白
貨號：

CSB-BP897495HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人KLF12重組蛋白
貨號：

CSB-MP897495HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

KLF12
Uniprot No.：

Q9Y4X4
別名：

2700063E05Rik; AI225908; AI315654; AP-2 repressor; AP-2rep; AP-2rep transcription factor; AP2REP; B130052C06Rik; D530033K05Rik; HSPC122; KLF12; KLF12 zinc finger transcriptional repressor; KLF12_HUMAN; Krueppel like factor 12; Krueppel-like factor 12; OTTHUMP00000018503; Transcriptional repressor AP 2rep ; Transcriptional repressor AP-2rep
種屬：

Homo sapiens (Human)
蛋白長度：

full length protein
表達區域：

1-402
氨基酸序列

MNIHMKRKTI KNINTFENRM LMLDGMPAVR VKTELLESEQ GSPNVHNYPD MEAVPLLLNN VKGEPPEDSL SVDHFQTQTE PVDLSINKAR TSPTAVSSSP VSMTASASSP SSTSTSSSSS SRLASSPTVI TSVSSASSSS TVLTPGPLVA SASGVGGQQF LHIIHPVPPS SPMNLQSNKL SHVHRIPVVV QSVPVVYTAV RSPGNVNNTI VVPLLEDGRG HGKAQMDPRG LSPRQSKSDS DDDDLPNVTL DSVNETGSTA LSIARAVQEV HPSPVSRVRG NRMNNQKFPC SISPFSIEST RRQRRSESPD SRKRRIHRCD FEGCNKVYTK SSHLKAHRRT HTGEKPYKCT WEGCTWKFAR SDELTRHYRK HTGVKPFKCA DCDRSFSRSD HLALHRRRHM LV
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Confers strong transcriptional repression to the AP-2-alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter.
基因功能參考文獻：
1. Results confirmed that KLF12 was highly expressed in nasopharyngeal carcinoma (NPC) tissues, and over-expressed KLF12 promoted NPC cell proliferation, while silencing KLF12 suppressed it. Furthermore, KLF12 was found to be a direct target for miR-1207 at its 3'-UTR mRNA. PMID: 30243935
2. Data indicate Kruppel-like factor 12 protein (KLF12) as a metastasis-suppressor gene whose loss of function is associated with anoikis resistance through control of the cell cycle. PMID: 26455320
3. KLF12 promotes tumor growth by directly activating early growth response protein 1 (EGR1). The levels of KLF12 and EGR1 correlate synergistically with a poor prognosis. These results indicate that KLF12 likely plays an important role in CRC and could serve as a potential prognostic marker and therapeutic target. PMID: 27442508
4. the overexpression of miR-141 augments anoikis resistance in ovarian cancer cells by targeting and repressing the expression of KLF12, which, in turn, competes for binding sites in the survivin promoter with Sp1. The subsequent increase in survivin then protects ovarian cancer cells against anoikis by blocking the intrinsic apoptotic activity. PMID: 28095864
5. Data show Kruppel-like factor 12 (KLF12) impairs endometrial decidualization by transcriptionally repressing Nur77 protein, and Nur77 overexpression reverses the poor decidual response of endometrial stromal cells (hESCs) in recurrent implantation failure (RIF) patients. PMID: 28359310
6. SLC29A1 rs760370 and KLF12 rs9543524 SNPs are associated with treatment induced thrombocytopenia in chronic hepatitis C patients treated with PEGIFN2b/ribavirin/combination. PMID: 26750805
7. our results supported that miR-205 was a miR specific to basal-like breast carcinoma (BLBC). which functioned as tumor suppressor gene through directly targeting and negatively regulating proto-oncogene KLF12. miR-205 dysregulation was involved in invasion and apoptosis. miR-205 and KLF12 provided a potential diagnosis biomarker and therapeutic approach for BLBC. PMID: 27278159
8. Overexpression of KLF12 is associated with gastric cancer. PMID: 27468717
9. Elevated KLF12 expression was accompanied by decreased FOXO1 expression in the endometria of patients with repeated implantation failure. PMID: 26223982
10. overexpression of KLF12 in endometrial stromal cells significantly repressed the expression and secretion of decidualization biomarker genes and their products decidual prolactin and insulin-like growth factor binding protein-1 PMID: 23458459
11. The KLF12 rs1324913 A allele homozygous genotype is a possible predictor of Rheumatoid Arthritis. PMID: 22150086
12. no association of genetic polymorphism with rheumatoid arthritis in Spanish and Dutch cohorts PMID: 21658422
13. In a large UK cohort of patients with rheumatoid arthritis, results have failed to add to the evidence for association at the KLF12 locus reported to be associated with rheumatoid arthritis in independent Spanish cohorts. PMID: 19907058
14. KLF12 as a new susceptibility gene for rheumatoid arthritis. PMID: 18668548
15. Overexpression of Kruppel-like factor 12 is associated with gastric cancer progression. PMID: 19588488
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亞細胞定位：

Nucleus.
蛋白家族：

Sp1 C2H2-type zinc-finger protein family
數據庫鏈接：

HGNC: 6346

OMIM: 607531

KEGG: hsa:11278

STRING: 9606.ENSP00000366894

UniGene: Hs.373857