Recombinant Human Inositol oxygenase (MIOX)

中文名稱：

人MIOX重組蛋白
貨號：

CSB-YP866220HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人MIOX重組蛋白
貨號：

CSB-EP866220HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人MIOX重組蛋白
貨號：

CSB-EP866220HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人MIOX重組蛋白
貨號：

CSB-BP866220HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人MIOX重組蛋白
貨號：

CSB-MP866220HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
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靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

MIOX
Uniprot No.：

Q9UGB7
別名：

0610009I10Rik; AI314022; Aldehyde reductase-like 6; ALDRL6; C85427; Inositol oxygenase; Kidney-specific protein 32; KSP32; MGC90217; MI oxygenase; miox; MIOX_HUMAN; Myo-inositol oxygenase; Renal-specific oxidoreductase; RSOR
種屬：

Homo sapiens (Human)
蛋白長度：

full length protein
表達區域：

1-285
氨基酸序列

MKVTVGPDPS LVYRPDVDPE VAKDKASFRN YTSGPLLDRV FTTYKLMHTH QTVDFVRSKH AQFGGFSYKK MTVMEAVDLL DGLVDESDPD VDFPNSFHAF QTAEGIRKAH PDKDWFHLVG LLHDLGKVLA LFGEPQWAVV GDTFPVGCRP QASVVFCDST FQDNPDLQDP RYSTELGMYQ PHCGLDRVLM SWGHDEYMYQ VMKFNKFSLP PEAFYMIRFH SFYPWHTGRD YQQLCSQQDL AMLPWVREFN KFDLYTKCPD LPDVDKLRPY YQGLIDKYCP GILSW
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

基因功能參考文獻：
1. Our results suggest that serum MIOX levels do not change in polycystic ovary syndrome. It was, therefore, concluded that myoinositol deficiency observed in PCOS was not related to the level of MIOX enzyme which cleaves myoinositol. PMID: 29187000
2. these findings highlight the epigenetic regulation of MIOX in the pathogenesis of diabetic tubulopathy. PMID: 28208054
3. Data suggest that MIOX expression/activity is up-regulated in kidneys tubules during oxidative stress (as in obesity and diabetic nephropathy); up-regulation of MIOX activity is related to phosphorylation of serine/threonine residues. PMID: 26578517
4. results demonstrated that the polymorphism (rs761745) in the promoter region of myo-inositol oxygenase(MIOX) gene may be associated with the development of type 1 diabetes mellitus in our studied population PMID: 19896870
5. Molecular cloning and characterization of myo-inositol oxygenase as a 33kDa protein. PMID: 15504367
6. expression of MIOX is up-regulated by a positive feedback mechanism where xylitol, one of the products of MI catabolism via the glucuronate-xylulose pathway, induces an overexpression of MIOX PMID: 15778219
7. myo-inositol oxygenase (MIOX) PMID: 11716759
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亞細胞定位：

Cytoplasm.
蛋白家族：

Myo-inositol oxygenase family
組織特異性：

Kidney specific.
數據庫鏈接：

HGNC: 14522

OMIM: 606774

KEGG: hsa:55586

STRING: 9606.ENSP00000216075

UniGene: Hs.129227