Recombinant Human Inositol 1,4,5-trisphosphate receptor-interacting protein (ITPRIP)

中文名稱：

人ITPRIP重組蛋白
貨號：

CSB-YP810278HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人ITPRIP重組蛋白
貨號：

CSB-EP810278HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人ITPRIP重組蛋白
貨號：

CSB-EP810278HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人ITPRIP重組蛋白
貨號：

CSB-BP810278HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人ITPRIP重組蛋白
貨號：

CSB-MP810278HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

ITPRIP
Uniprot No.：

Q8IWB1
別名：

ITPRIP; DANGER; KIAA1754Inositol 1,4,5-trisphosphate receptor-interacting protein; Protein DANGER
種屬：

Homo sapiens (Human)
蛋白長度：

Full Length of Mature Protein
表達區域：

16-547
氨基酸序列

IINHP LLFPRENATV PENEEEIIRK MQAHQEKLQL EQLRLEEEVA RLAAEKEALE QVAEEGRQQN ETRVAWDLWS TLCMILFLMI EVWRQDHQEG PSPECLGGEE DELPGLGGAP LQGLTLPNKA TLGHFYERCI RGATADAART REFLEGFVDD LLEALRSLCN RDTDMEVEDF IGVDSMYENW QVDRPLLCHL FVPFTPPEPY RFHPELWCSG RSVPLDRQGY GQIKVVRADG DTLSCICGKT KLGEDMLCLL HGRNSMAPPC GDMENLLCAT DSLYLDTMQV MKWFQTALTR AWKGIAHKYE FDLAFGQLDS PGSLKIKFRS GKFMPFNLIP VIQCDDSDLY FVSHLPREPS EGTPASSTDW LLSFAVYERH FLRTTLKALP EGACHLSCLQ IASFLLSKQS RLTGPSGLSS YHLKTALLHL LLLRQAADWK AGQLDARLHE LLCFLEKSLL QKKLHHFFIG NRKVPEAMGL PEAVLRAEPL NLFRPFVLQR SLYRKTLDSF YEMLKNAPAL ISEYSLHVPS DQPTPKS
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Enhances Ca(2+)-mediated inhibition of inositol 1,4,5-triphosphate receptor (ITPR) Ca(2+) release.
基因功能參考文獻：
1. The suggested model of how long noncoding RNAs (lncI) TPRIP-1 orchestrates signal transduction for IFN production illustrates the essential role of lncRNAs in virus elimination. PMID: 29899107
2. High DANGER expression is involved in high glucose-induced radioresistance through inhibiting DAPK-mediated anoikis in non-small cell lung cancer. PMID: 26769850
3. DANGER appears to allosterically modulate the sensitivity of IP(3) RtoCa(2+) inhibition, which likely alters IP(3)R-mediated Ca(2+) dynamics in cells where DANGER and IP(3)R are co-expressed PMID: 16990268
亞細胞定位：

Cell membrane; Single-pass type I membrane protein. Nucleus outer membrane; Single-pass type I membrane protein.
蛋白家族：

ITPRIP family
組織特異性：

Detected in brain where it is concentrated in cerebellar Purkinje cells (at protein level).
數據庫鏈接：

HGNC: 29370

KEGG: hsa:85450

UniGene: Hs.523252