Recombinant Human Homeobox protein Nkx-2.6 (NKX2-6)

中文名稱：

人NKX2-6重組蛋白
貨號：

CSB-YP015846HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人NKX2-6重組蛋白
貨號：

CSB-EP015846HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人NKX2-6重組蛋白
貨號：

CSB-EP015846HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人NKX2-6重組蛋白
貨號：

CSB-BP015846HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人NKX2-6重組蛋白
貨號：

CSB-MP015846HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

NKX2-6
Uniprot No.：

A6NCS4
別名：

NKX2-6; NKX2F; Homeobox protein Nkx-2.6; Homeobox protein NK-2 homolog F
種屬：

Homo sapiens (Human)
蛋白長度：

Full length protein
表達區域：

1-301
氨基酸序列

MLLSPVTSTP FSVKDILRLE RERSCPAASP HPRVRKSPEN FQYLRMDAEP RGSEVHNAGG GGGDRKLDGS EPPGGPCEAV LEMDAERMGE PQPGLNAASP LGGGTRVPER GVGNSGDSVR GGRSEQPKAR QRRKPRVLFS QAQVLALERR FKQQRYLSAP EREHLASALQ LTSTQVKIWF QNRRYKCKRQ RQDKSLELAG HPLTPRRVAV PVLVRDGKPC LGPGPGAPAF PSPYSAAVSP YSCYGGYSGA PYGAGYGTCY AGAPSGPAPH TPLASAGFGH GGQNATPQGH LAATLQGVRA W
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Acts as a transcriptional activator. In conjunction with NKX2-5, may play a role in both pharyngeal and cardiac embryonic development.
基因功能參考文獻：
1. This study firstly links NKX2.6 loss-of-function mutation with increased susceptibility to isolated VSD. PMID: 25380965
2. Data associated genetically defective NK2 homeobox 6 (NKX2-6) with enhanced susceptibility to atrial fibrillation (AF). PMID: 25319568
3. Heterozygous mutations in Nkx2.6, p.V176M and p.K177X, were identified in 2 unrelated patients, one with tetralogy of Fallot and one with double outlet of right ventricle and ventricular septal defect. Increased vulnerability to TOF or DORV is discussed. PMID: 25195019
4. NKX2-6 plays a role in human cardiogenesis. PMID: 24421281
5. weakly activates transcription of a Cx40 promoter, may have role in heart development PMID: 15649947
6. NKX2.5/NKX2.6 mutations are not a common cause of isolated type 1 truncus arteriosus in a small cohort of multiethnic cases. PMID: 18939937
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相關疾病：

Conotruncal heart malformations (CTHM)
亞細胞定位：

Nucleus.
蛋白家族：

NK-2 homeobox family
數據庫鏈接：

HGNC: 32940

OMIM: 217095

KEGG: hsa:137814

STRING: 9606.ENSP00000320089

UniGene: Hs.532654