Recombinant Human HLA class II histocompatibility antigen, DO beta chain (HLA-DOB), partial

中文名稱：

人HLA-DOB重組蛋白
貨號：

CSB-YP318411HU
規格：
來源：

Yeast
其他：

中文名稱：

人HLA-DOB重組蛋白
貨號：

CSB-EP318411HU
規格：
來源：

E.coli
其他：

中文名稱：

人HLA-DOB重組蛋白
貨號：

CSB-EP318411HU-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人HLA-DOB重組蛋白
貨號：

CSB-BP318411HU
規格：
來源：

Baculovirus
其他：

中文名稱：

人HLA-DOB重組蛋白
貨號：

CSB-MP318411HU
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

HLA-DOB
Uniprot No.：

P13765
別名：

HLA-DOBHLA class II histocompatibility antigen; DO beta chain; MHC class II antigen DOB
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells. Modifies peptide exchange activity of HLA-DM.
基因功能參考文獻：
1. results indicate that HLA-DOB is co-inherited with DQA2-B2 genes and thus may contribute to HCV and HBV persistence PMID: 28813660
2. HLA-DO beta-chain antigens are ubiquitinated by MARCH family E3 ligases 1, 8, and 9. PMID: 23400868
3. HLA-DOB mutations were analyzed for association with autoimmune diseases and B-cell leukemias. PMID: 12439622
4. A new DOB allele, DOB*010103, was identified in the Korean population during sequence-based HLA-DOB typing. PMID: 15730525
亞細胞定位：

Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=Complexes with HLA-DM molecule during intracellular transport and in endosomal/lysosomal compartments. Heterotetramerization is necessary to exit the ER.
蛋白家族：

MHC class II family
數據庫鏈接：

HGNC: 4937

OMIM: 142920

KEGG: hsa:3112

STRING: 9606.ENSP00000390020

UniGene: Hs.1802