Recombinant Human Glycylpeptide N-tetradecanoyltransferase 2 (NMT2)

中文名稱：

人NMT2重組蛋白
貨號：

CSB-YP015901HU
規格：
來源：

Yeast
其他：

中文名稱：

人NMT2重組蛋白
貨號：

CSB-EP015901HU-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人NMT2重組蛋白
貨號：

CSB-BP015901HU
規格：
來源：

Baculovirus
其他：

中文名稱：

人NMT2重組蛋白
貨號：

CSB-MP015901HU
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

NMT2
Uniprot No.：

O60551
別名：

EC 2.3.1.97; Glycylpeptide N tetradecanoyltransferase 2; Glycylpeptide N-tetradecanoyltransferase 2; Myristoyl CoA:protein N myristoyltransferase 2; Myristoyl-CoA:protein N-myristoyltransferase 2; N-myristoyltransferase 2; NMT 2; NMT2; NMT2_HUMAN; Peptide N myristoyltransferase 2; Peptide N-myristoyltransferase 2; Type II N myristoyltransferase ; Type II N-myristoyltransferase
種屬：

Homo sapiens (Human)
蛋白長度：

Full length protein
表達區域：

1-498
氨基酸序列

MAEDSESAAS QQSLELDDQD TCGIDGDNEE ETEHAKGSPG GYLGAKKKKK KQKRKKEKPN SGGTKSDSAS DSQEIKIQQP SKNPSVPMQK LQDIQRAMEL LSACQGPARN IDEAAKHRYQ FWDTQPVPKL DEVITSHGAI EPDKDNVRQE PYSLPQGFMW DTLDLSDAEV LKELYTLLNE NYVEDDDNMF RFDYSPEFLL WALRPPGWLL QWHCGVRVSS NKKLVGFISA IPANIRIYDS VKKMVEINFL CVHKKLRSKR VAPVLIREIT RRVNLEGIFQ AVYTAGVVLP KPIATCRYWH RSLNPRKLVE VKFSHLSRNM TLQRTMKLYR LPDVTKTSGL RPMEPKDIKS VRELINTYLK QFHLAPVMDE EEVAHWFLPR EHIIDTFVVE SPNGKLTDFL SFYTLPSTVM HHPAHKSLKA AYSFYNIHTE TPLLDLMSDA LILAKSKGFD VFNALDLMEN KTFLEKLKFG IGDGNLQYYL YNWRCPGTDS EKVGLVLQ
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins.
基因功能參考文獻：
1. ligand binding properties of the NMT/ACBD6 complex can explain how the NMT reaction can proceed in the presence of the very abundant competitive substrate, C(16)-CoA. PMID: 26621918
2. induction of NMT2 may play a central role in dioxin carcinogenicity. PMID: 11731439
3. NMT1 and NMT2 have only partially overlapping functions; NMT1 is critical for tumor cell proliferation PMID: 16123142
4. Involved in progression and regulation of telomerase PMID: 16364039
5. Protein-protein interaction of NMTs revealed that m-calpain interacts with NMT1 while caspase-3 interacts with NMT2. PMID: 16530191
6. Disruption of the gene for NMT2 by a t(8;10) translocation in a male with hypogonadism. PMID: 17568424
7. Nef is preferentially myristoylated by NMT2, suggesting that selective inhibition of NMT2 may provide a novel means of blocking HIV virulence. PMID: 18089753
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亞細胞定位：

Cytoplasm. Membrane; Peripheral membrane protein.
蛋白家族：

NMT family
數據庫鏈接：

HGNC: 7858

OMIM: 603801

KEGG: hsa:9397

STRING: 9606.ENSP00000367407

UniGene: Hs.60339