Recombinant Human F-box only protein 42 (FBXO42)

中文名稱：

人FBXO42重組蛋白
貨號：

CSB-YP744044HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人FBXO42重組蛋白
貨號：

CSB-EP744044HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人FBXO42重組蛋白
貨號：

CSB-EP744044HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人FBXO42重組蛋白
貨號：

CSB-BP744044HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人FBXO42重組蛋白
貨號：

CSB-MP744044HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

FBXO42
Uniprot No.：

Q6P3S6
別名：

F box only protein 42 ; F box protein 42; F-box only protein 42; Fbx 42; FBX42 ; FBX42_HUMAN; FBXO 42; FBXO42; JFK; Just one F-box and Kelch domain-containing protein; KIAA1332
種屬：

Homo sapiens (Human)
蛋白長度：

full length protein
表達區域：

1-717
氨基酸序列

MASSSDSEDD SFMAVDQEET VLEGTMDQDE EPHPVLEAEE TRHNRSMSEL PEEVLEYILS FLSPYQEHKT AALVCKQWYR LIKGVAHQCY HGFMKAVQEG NIQWESRTYP YPGTPITQRF SHSACYYDAN QSMYVFGGCT QSSCNAAFND LWRLDLNSKE WIRPLASGSY PSPKAGATLV VYKDLLVLFG GWTRPSPYPL HQPERFFDEI HTYSPSKNWW NCIVTTHGPP PMAGHSSCVI DDKMIVFGGS LGSRQMSNDV WVLDLEQWAW SKPNISGPSP HPRGGQSQIV IDDATILILG GCGGPNALFK DAWLLHMHSG PWAWQPLKVE NEEHGAPELW CHPACRVGQC VVVFSQAPSG RAPLSPSLNS RPSPISATPP ALVPETREYR SQSPVRSMDE APCVNGRWGT LRPRAQRQTP SGSREGSLSP ARGDGSPILN GGSLSPGTAA VGGSSLDSPV QAISPSTPSA PEGYDLKIGL SLAPRRGSLP DQKDLRLGSI DLNWDLKPAS SSNPMDGMDN RTVGGSMRHP PEQTNGVHTP PHVASALAGA VSPGALRRSL EAIKAMSSKG PSASAALSPP LGSSPGSPGS QSLSSGETVP IPRPGPAQGD GHSLPPIARR LGHHPPQSLN VGKPLYQSMN CKPMQMYVLD IKDTKEKGRV KWKVFNSSSV VGPPETSLHT VVQGRGELII FGGLMDKKQN VKYYPKTNAL YFVRAKR
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Specifically recognizes p53/TP53, promoting its ubiquitination and degradation.
基因功能參考文獻：
1. SCF(JFK) as a bona fide E3 ligase for ING4 and unraveled the JFK-ING4-NF-kappaB axis as an important player in the development and progression of breast cancer PMID: 25792601
2. The findings of this study suggest that a haplotype of the FBXO42 gene might be associated with a higher susceptibility to PD. PMID: 24063688
3. Substrate phosphorylation and feedback regulation in JFK-promoted p53 destabilization. PMID: 21127074
4. JFK promotes p53 turnover through assembly of an SCF (Skp1-Cul1-F-box) complex, revealing a pathway for the control of p53 degradation and providing a link between the SCF complex and p53 regulation. PMID: 19509332
數據庫鏈接：

HGNC: 29249

OMIM: 609109

KEGG: hsa:54455

STRING: 9606.ENSP00000364742

UniGene: Hs.522384