Recombinant Human Erythrocyte band 7 integral membrane protein (STOM)

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中文名稱：

人STOM重組蛋白
貨號：

CSB-EP022862HU
說明書：

MSDS Datasheet
規格：

￥1836
圖片：
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
其他：

產品詳情
產品評價
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靶點詳情

產品詳情

純度：

Greater than 90% as determined by SDS-PAGE.
基因名：

STOM
Uniprot No.：

P27105
別名：

BND7 ; EPB7 ; EPB72; Erythrocyte band 7 integral membrane protein; Erythrocyte membrane protein band 7.2 (stomatin) ; Erythrocyte surface protein band 7.2; Protein 7.2b; STOM; STOM_HUMAN; Stomatin
種屬：

Homo sapiens (Human)
蛋白長度：

Full Length
來源：

E.coli
分子量：

47.7kDa
表達區域：

1-288aa
氨基酸序列

MAEKRHTRDSEAQRLPDSFKDSPSKGLGPCGWILVAFSFLFTVITFPISIWMCIKIIKEYERAIIFRLGRILQGGAKGPGLFFILPCTDSFIKVDMRTISFDIPPQEILTKDSVTISVDGVVYYRVQNATLAVANITNADSATRLLAQTTLRNVLGTKNLSQILSDREEIAHNMQSTLDDATDAWGIKVERVEIKDVKLPVQLQRAMAAEAEASREARAKVIAAEGEMNASRALKEASMVITESPAALQLRYLQTLTTIAAEKNSTIVFPLPIDMLQGIIGAKHSHLG
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 6xHis-SUMO-tagged
產品提供形式：

Liquid or Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

3-7 business days
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

Regulates ion channel activity and transmembrane ion transport. Regulates ASIC2 and ASIC3 channel activity.
基因功能參考文獻：
1. we show that stomatin modulates the transport activity of AE1 through a direct protein-protein interaction. PMID: 28387307
2. These results may suggest that stomatin is a new prognostic indicator for HER2-positive breast cancer PMID: 27577936
3. FRAP analyses indicate that the stomatin C-terminus is the dominant entity for lateral mobility and binding site for the cortical actin cytoskeleton PMID: 28575093
4. This study showed that cells expressing more stomatin or exposed to exogenous stomatin are more prone to undergoing cell fusion; during osteoclastogenesis, depletion of stomatin inhibited cell fusion but had little effect on tartrate-resistant acid phosphatase production. PMID: 27663861
5. Authors took a proteomic approach to identify stomatin, a member of the integral proteins of lipid rafts, as a cellular protein interacting with hepatitis C virus NS5B. PMID: 25262680
6. Stomatin protein expression is down-regulated in 80% of non-small cell lung cancer samples. PMID: 24533441
7. upregulation of stomatin by hypoxia and dex may enhance the barrier function of alveolar epithelia and mediate the adaptive role of glucocorticoid to hypoxia PMID: 23672602
8. Stomatin interacts with GLUT1/SLC2A1, band 3/SLC4A1, and aquaporin-1 in human erythrocyte membrane domains PMID: 23219802
9. [review] Stomatin family member STOM is oligomeric; it localizes mostly to membrane domains and has been shown to modulate ion channel activity. PMID: 21501885
10. The study indicates that stomatin, sorcin, and synexin are echinophilic membrane components that mainly locate outside GM1 rafts in the human erythrocyte membrane. PMID: 20858460
11. This study demonstrated the existence of alpha-granular lipid rafts and suggests an important role for stomatin in the organization and function of alpha granules. PMID: 12130500
12. stomatin is localized to detergent-insoluble domains of neutrophil granule membranes PMID: 12429719
13. in stomatocytosis there is no significant abnormality in stomatin gene sequence instead, deficiency of stomatin from red cells appears to be due to a loss of stomatin from these red cells on maturation in the bone marrow and in the circulation. PMID: 12750157
14. study of strongly homologous stomatin-like genes in prokaryotes reveals a close connection with a gene coding for a hydrophobic protein with a probable serine protease motif; stomatin could be a partner protein for a membrane-bound proteolytic process PMID: 15121101
15. stomatin binds to and alters the gating of acid-sensing ion channels PMID: 15471860
16. A small C-terminal region of stomatin that is largely hydrophobic (residues 264-272) is crucial for oligomerization, whereas the N-terminal domain (residues 1-20) and the last 12 C-terminal amino acids (residues 276-287) are not essential. PMID: 16766530
17. The stomatin-actin association is important in maintaining the structure and in modulating the function of stomatin-containing membrane rafts in red cells. PMID: 17961506
18. Data indicate that a stomatin-specific, raft-based process is involved in storage-associated vesiculation. PMID: 18067507
19. Stomatin-like protein-1 interacts with stomatin and is targeted to late endosomes PMID: 19696025
20. Stomatin is a member of an ancient protein family that has extremely well conserved homologues in all three domains of life. PMID: 18267007
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亞細胞定位：

Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell membrane; Lipid-anchor; Cytoplasmic side. Membrane raft. Melanosome. Cytoplasmic vesicle.
蛋白家族：

Band 7/mec-2 family
組織特異性：

Detected in erythrocytes (at protein level). Widely expressed.
數據庫鏈接：

HGNC: 3383

OMIM: 133090

KEGG: hsa:2040

STRING: 9606.ENSP00000286713

UniGene: Hs.253903