Recombinant Human E3 ubiquitin-protein ligase PDZRN3 (PDZRN3), partial

中文名稱：

人PDZRN3重組蛋白
貨號：

CSB-YP891797HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人PDZRN3重組蛋白
貨號：

CSB-EP891797HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人PDZRN3重組蛋白
貨號：

CSB-EP891797HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人PDZRN3重組蛋白
貨號：

CSB-BP891797HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人PDZRN3重組蛋白
貨號：

CSB-MP891797HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

PDZRN3
Uniprot No.：

Q9UPQ7
別名：

E3 ubiquitin-protein ligase PDZRN3; KIAA1095; Ligand of Numb protein X 3; likely ortholog of mouse semaF cytoplasmic domain associated protein 3; LNX3; PDZ domain containing ring finger 3 ; PDZ domain-containing RING finger protein 3; Pdzrn3; Protein SEMACAP3; PZRN3_HUMAN; SEMACAP3; Semaphorin cytoplasmic domain associated protein ; Semaphorin cytoplasmic domain-associated protein 3; SEMCAP3
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

E3 ubiquitin-protein ligase. Plays an important role in regulating the surface level of MUSK on myotubes. Mediates the ubiquitination of MUSK, promoting its endocytosis and lysosomal degradation. Might contribute to terminal myogenic differentiation.
基因功能參考文獻：
1. Authors show that HPV-16 and HPV-18 E6 can target PDZRN3 in a PDZ- and proteasome-dependent manner and provide a connection between the papillomavirus life cycle and differentiation-related STAT signaling. PMID: 25355882
2. a novel partner of Kidins220/ARMS PMID: 22609016
3. These results indicate that PDZRN3 plays an important role in negative feedback control of BMP-2-induced osteoblast differentiation in C2C12 cells through inhibition of Wnt3a-beta-catenin signaling. PMID: 20668165
亞細胞定位：

Cell junction, synapse. Cytoplasm.
組織特異性：

Widely expressed, including in the heart, skeletal muscle and liver and, at lower levels, in the brain, colon, small intestine, placenta and lung. Down-regulated in ovarian serous papillary tumors.
數據庫鏈接：

HGNC: 17704

OMIM: 609729

KEGG: hsa:23024

STRING: 9606.ENSP00000263666

UniGene: Hs.660347