1. Individuals are carrying DUSP6 rs2279574 AA and AC genotypes associated with an increased risk in developing lung squamous carcinoma in Han Chinese and with advanced NSCLC stages. PMID: 29578153
2. DUSP6 expression in skeletal muscle was reduced by 43% just after exercise and remained below pre-exercise level after 2 h recovery. PMID: 28989118
3. Data show that oxidative stress and MAP kinase phosphatase 3 (MKP3) inhibition play a critical role in procyanidin B2 3,3''-di-O-gallate (B2G2)-induced cell death in prostate cancer (PCa) cells through sustained activation of both ERK1/2 and AMPKalpha. PMID: 28876465
4. High DUSP6 expression is associated with Lung Squamous Cell Carcinoma. PMID: 27613525
5. Authors demonstrate the broad applicability of this recombination-based method and they proved its potential to identify new drug targets via the identification of the tumor suppressor DUSP6 as potential synthetic lethal target in melanoma cell lines with BRAF V600E mutations and high DUSP6 expression. PMID: 28423600
6. PICSAR has a role in promoting cSCC progression via activation of extracellular signal-regulated kinase 1/2 signaling pathway by downregulating DUSP6 expression PMID: 27049681
7. DUSP6 rs2279574 SNPs was not associated with chemoradiotherapy response, whereas tumor regression, weight loss, clinical stage, and cigarette smoking were independent prognostic predictors for these Chinese patients with non-small cell lung cancer. PMID: 28231233
8. DNA samples from each patient were genotyped for DUSP6 and TOP2A SNPs PMID: 27156317
9. Suppression of the FOXA1/DUSP6 signaling pathway may contribute to the development of Hirschsprung disease. PMID: 26097584
10. These observations led us to conclude that increased TSH signaling overcomes OIS and is essential for B-RafV600E-induced papillary thyroid carcinogenesis. PMID: 25499223
11. Dusp6 expression was higher in progestin-sensitive atypical endometrial hyperplasia groups compared with progestin-resistant groups. After treatment, Dusp6 expression was upregulated in progestin-sensitive groups, but not in progestin-resistant groups. PMID: 25451692
12. Our results suggest that DUSP6 gene expression in tumour samples may be a prognostic marker in NSCLC PMID: 25344212
13. DUSP6 downregulated the expression of matrix metallopeptidase 3. PMID: 25241655
14. These results therefore indicate that p53-mediated up-regulation of MKP-3 contributes to the establishment of the senescent cellular phenotype through dephosphorylating ERK1/2 PMID: 25414256
15. Downregulation of Dusp6, Sprouty4, and Sef--negative modulators of FGF2/ERK1/2 signaling--was present in eutopic endometria of adenomyosis, which may play critical roles in the development of adenomyosis. PMID: 24681741
16. Higher expression of DUSP6 in tumor tissue, than in peritumor tissue, is associated with the recurrence after curative resection of HCC, and the relative tumor DUSP6 expression has good power to predict the recurrence of HCC. PMID: 24709168
17. suggest an important role for DeltaNp63alpha in preventing cancer metastasis by inhibition of Erk2 signaling via MKP3 subscribing PMID: 23246965
18. Dusp6 overexpression is involved in the pathogenesis and development of human endometrial adenocarcinoma. PMID: 23419500
19. Increased DUSP6 expression is associated with papillary thyroid carcinoma. PMID: 24222120
20. Depletion of DUSP6 reduced the viability of cancer cell lines and increased the cytotoxicity of EGFR and other targeted inhibitors, and cytotoxic agents. PMID: 23839489
21. missense mutation, c.545C>T (p.Ser182Phe), in the DUSP6 gene may be genetically linked to the Class III malocclusion PMID: 23965468
22. DUSP6 is overexpressed in papillary and poorly differentiated thyroid carcinoma and contributes to neoplastic properties of thyroid cancer cells. PMID: 23132790
23. The results provide insights on the modulatory role of p53 in the survival pathway by up-regulating DUSP6. PMID: 23108049
24. study reports that naive CD4 T cells from elderly individuals have reduced signaling capacity of the ERK pathway; the underlying mechanism is an age-related decline in miR-181a expression and associated rise in levels of DUSP6 expression PMID: 23023500
25. ischemia/reperfusion inhibited eNOS expression by inactivation of ERK1/2, leading to decreased NO formation through a MKP-3-dependent mechanism in endothelial cells PMID: 22848708
26. DUSP6 plays an important role in the pathogenesis of bipolar disorder, particularly in women. PMID: 22155192
27. MESP2, HES7 and DUSP6 genes may not be involved in the etiopathogenesis of sporadic and non-syndromic CS in Chinese Han population. PMID: 22744456
28. A link between DUSP6 expression and high-risk features of papillary thyroid carcinoma suggested that DUSP6 is an important independent factor affecting the signaling pathways in established papillary thyroid carcinoma. PMID: 22535643
29. DUSP6 is important in melanoma and it plays a different role in the distinct subtype of mouse melanoma compared with that in classic human melanoma. PMID: 22171919
30. caspase-3 cleavage of MKP3 down-regulates MKP3 full length and renders active MKP3 fragments, which may participate in novel regulatory pathways controlling the subcellular localization and activation of ERK1/2 during apoptosis. PMID: 22504224
31. Studies identified a single gene DUSP6, whose expression was associated with sensitivity to GSK1120212. PMID: 22169769
32. Studies indicate that ERKs stimulate their own dephosphorylation by directly binding to phosphatases, such as MKP-3, and activating them. PMID: 22028468
33. Loss of DUSP6 is associated with esophageal squamous cell carcinoma and nasopharyngeal carcinoma. PMID: 21387288
34. DUSP6 plays an important role in cancer resistance in different subtypes of non-small cell lung carcinoma. PMID: 21680106
35. upregulation of DUSP6 exerts a tumor-promoting role in human glioblastomas exacerbating the malignant phenotype. PMID: 21499306
36. MKP3 not only controls the activities of ERK2 and p38alpha but also mediates cross-talk between these two MAPK pathways. PMID: 21454500
37. This study shows that post-transcriptional regulation is a key process in the control of DUSP6 expression. PMID: 20665674
38. DUSP6 methylation is a rare event in endometrial cancer. Silencing of the DUSP6 phosphatase is unlikely to contribute to constitutive activation of the ERK kinase cascade in endometrial cancer. PMID: 20638106
39. Dual specificity phosphatase 6 (DUSP6) is an ETS-regulated negative feedback mediator of oncogenic ERK signaling in lung cancer cells. PMID: 20097731
40. Angiotensin II-induced upregulation of MAP kinase phosphatase-3 mRNA levels mediates endothelial cell apoptosis PMID: 11998972
41. Results show that DUSP6 exerts apparent tumor-suppressive effects in vitro and suggest that DUSP6 is a strong candidate tumor suppressor gene at 12q22 locus. PMID: 12759238
42. Constitutive induction of p-Erk1/2 accompanied by reduced activities of protein phosphatases 1 and 2A and MKP3 due to reactive oxygen species during cellular senescence. PMID: 12840032
43. Study gives first direct evidence that the N-terminal domain of MKP3 mediates intramolecular dephosphorylation between the monomeric form of phosphorylated extracellular signal-regulated kinase and a monomer of MKP3. PMID: 14690430
44. cytoplasmic localization of MKP3 is mediated by a chromosome region maintenance-1 (CRM1)-dependent nuclear export pathway; the ability of MKP3 to cause the cytoplasmic retention of ERK2 requires both a functional kinase interaction motif and NES PMID: 15269220
45. Hypermethylation with modification of histone deacetylation play an important role in transcriptional suppression of DUSP6 in human pancreatic cancer PMID: 15824892
46. Results suggest that the abrogation of DUSP6 is associated exclusively with progression from pancreatic intraepithelial neoplasia to the invasive ductal carcinoma. PMID: 15832194
47. Results demonstrate that in the Korean population DUSP6 may contribute to the etiology of bipolar disorder, but not schizophrenia. PMID: 16491131
48. Nuclear matrix proteins such as mutant Pyst1 and nucleophosmin 1 were downregulated, whereas eIF6 and beta-tubulin were upregulated during cell differentiation in hepatocarcinoma cells. PMID: 17569113
49. even upon over-expression DUSP6 fails to inactivate ERK5, confirming that it is indeed an ERK1/2-specific DUSP PMID: 18280112
50. MKP3 can act to enhance DAT function and is a phosphatase involved in regulating dynamin-dependent endocysis PMID: 18434601

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HGNC: 3072

OMIM: 602748

KEGG: hsa:1848

STRING: 9606.ENSP00000279488

UniGene: Hs.298654