Recombinant Human Dentin matrix acidic phosphoprotein 1 (DMP1)

中文名稱：

人DMP1重組蛋白
品名簡稱：

Recombinant Human DMP1 protein
貨號：

CSB-YP006967HU
說明書：

MSDS Datasheet
規(guī)格：

￥2208
圖片：
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Based on the SEQUEST from database of Yeast host and target protein, the LC-MS/MS Analysis result of CSB-YP006967HU could indicate that this peptide derived from Yeast-expressed Homo sapiens (Human) DMP1.

Based on the SEQUEST from database of Yeast host and target protein, the LC-MS/MS Analysis result of CSB-YP006967HU could indicate that this peptide derived from Yeast-expressed Homo sapiens (Human) DMP1.
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

Greater than 85% as determined by SDS-PAGE.
基因名：

DMP1
Uniprot No.：

Q13316
別名：

DMP1; Dentin matrix acidic phosphoprotein 1; DMP-1; Dentin matrix protein 1
種屬：

Homo sapiens (Human)
蛋白長度：

Full Length of Mature Protein
來源：

Yeast
分子量：

56.0 kDa
表達區(qū)域：

17-513aa
氨基酸序列

LPVTRYQNNESEDSEEWKGHLAQAPTPPLESSESSEGSKVSSEEQANEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQLKNIEIESRKLTVDAYHNKPIGDQDDNDCQDGY
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 6xHis-tagged
產品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Tris-based buffer,50% glycerol
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite.
基因功能參考文獻：
1. dentin matrix protein 1 was detected in the periodontal ligament co-localized with periostin in the vicinity of the cement PMID: 29289709
2. The Dentin matrix protein1 (Dmp1) is an acidic phosphoprotein of osteocytes proposed to participate in bone and dentin mineralization. PMID: 28247029
3. Thus, unspDMP-1 is a novel chromatin-enriched RNA that epigenetically regulates cellular proliferation of SQCC. PMID: 29278708
4. DMP1 might be a potential factor contributing to cardiovascular complications in dialysis patients. PMID: 27390906
5. DMP1 gene seems to be involved in genetic predisposition to Ankylosing spondylitis (AS). PMID: 26960368
6. DMP-1 immunostaining was higher for MTA and PC, confirming the reparative and bioinductive capacity of these materials. PMID: 25678029
7. This review will focus on the aberrant splicing of tumor suppressor/oncogenes that belong to the DMP1-ARF-MDM2-p53 pathway PMID: 26802432
8. Expressions of dentin matrix protein (DMP)-1 and osteopontin (OPN) were observed in both normal dentin and dentin from DGI-I affected patients, without significant differences PMID: 25578972
9. identify alternative splicing as a mechanism utilized by cancer cells to modulate the DMP1 locus through diminishing DMP1alpha tumour suppressor expression PMID: 25537728
10. The findings indicate that DMP-1 is a useful marker of osteogenic differentiation and mineralisation in soft tissue tumours PMID: 25630512
11. A family of autosomal recessive form of Hypophosphatemic rickets secondary to a DMP1 mutation located in the first coding exon of the gene, is reported. PMID: 25180662
12. Results suggest that FAM20C suppresses FGF23 production by enhancing DMP1 expression, and inactivating mutations in FAM20C cause FGF23-related hypophosphatemia by decreasing transcription of DMP1. PMID: 25026495
13. DMP1 may play an important role in maintaining the chondrogenic phenotype and its possible involvement in altered cartilage matrix remodelling and degradation in disease conditions like osteoarthritis. PMID: 24987156
14. DMP1 and DSPP were more abundant in carious than in sound samples. PMID: 24441185
15. DMP-1 is a matrix marker expressed around osteocytes in human woven and lamellar bone and is useful in identifying osteosarcoma and other bone-forming tumours. PMID: 23559304
16. Mutations in PHEX and DMP1 play a role in causing hypophosphatemic rickets. PMID: 22695891
17. DMP1 is regulated post-transcriptionally by let-7 during odontoblast differentiation. PMID: 22552299
18. DMP-1 stimulated production of IL-6/IL-8 from pulp fibroblasts. Inhibition of p38 mitogen-activated protein kinase pathway blocked proinflammatory effect on pulp fibroblasts. DMP-1 might participate in development of inflammatory changes in pulp. PMID: 22152625
19. Simvastatin plus all-trans retinoic acid reduces expression of WT1 and DMP1 in the promyelocytic leukemia cell line NB4. PMID: 22093791
20. DMP1 is specifically involved in signaling via extracellular matrix-cell surface interaction. PMID: 21642437
21. Data show the wide spectrum of genetic variation that can be seen in PHEX, FGF23 and DMP1 when screening a large cohort with hypophosphatemic rickets. PMID: 21050253
22. after VE-cadherin induction by DMP1, DMP1 inhibited VEGFR-2 phosphorylation and Src-mediated signaling; DMP1 is identified as a new specific inhibitor of VEGF-induced angiogenesis PMID: 21190990
23. possible role of dentine matrix protein 1 in the aetiology of [aggressive periodontitis] PMID: 21299946
24. clinical and laboratory observations in this family confirm that DMP1 has an important role in normal skeletal development and mineral homeostasis PMID: 20499351
25. Study shows the pivotal roles of Dmp1 in HER2/neu-p53 signaling and breast carcinogenesis. PMID: 21062982
26. study describes a Japanese family that includes 2 autosomal recessive hypophosphatemic rickets-affected siblings carrying a novel mutation of the DMP1 gene (98G>A, W33X), which leads to a truncated DMP protein with no putative biological function PMID: 20213538
27. The identified genetic mutation underscores the importance of DMP-1 mutations in the pathogenesis of autosomal recessive form of hypophosphatemia. PMID: 19796717
28. The patterns of expression of FGF-23, MEPE, and DMP1 differ markedly in trabecular bone, suggesting that individual osteocytes may have specialized functions. PMID: 19679205
29. Three SIBLINGs (small integrin-binding ligand, N-linked glycoproteins) enhance factor H's cofactor activity enabling MCP-like cellular evasion of complement-mediated attack. PMID: 11825898
30. DMP1 immunostaining intensity and extent scores were significantly higher in adenocarcinoma (p = 0.0004) and squamous carcinoma (p < 0.0001) samples compared with adjacent normal lung tissue PMID: 12929940
31. dentin matrix protein-1 is processed by Bone morphogenetic protein-1/Tolloid-like proteinases PMID: 14578349
32. Findings indicate that DMP1 immunohistochemistry is a useful tool for identifying phosphaturic mesenchymal tumors (PMTs). PMID: 15001995
33. a silencing cis-element may play a critical role in the regulation of DMP1 cell-specific expression PMID: 15108359
34. 8-kb region of the Dentin matrix protein 1 (DMP1) gene is a target for mechanotransduction in osteocytes, and its cis-regulatory activity may be correlated to local strain in bone PMID: 15728181
35. Dentin matrix protein 1 enhances invasion potential of colon cancer cells by bridging matrix metalloproteinase-9 to integrins and CD44 PMID: 16357164
36. analysis of a chondroitin sulfate chain attached to the bone dentin matrix protein 1 NH2-terminal fragment PMID: 16421105
37. DMP1 regulates the expression of the DSPP gene PMID: 16679514
38. Absence of DMP1 results in defective osteocyte maturation and increased FGF23 expression, leading to pathological changes in bone mineralization. PMID: 17033621
39. DMP1 may regulate FGF23 expression. PMID: 17033625
40. DMP1 has a role in breast cancer progression and bone metastases development PMID: 17136477
41. Thus, our results suggest that Cbfalpha1 upregulates DMP1 gene expression differentially that may contribute to the spatial-temporal expression pattern of DMP1 during odontoblast differentiation. PMID: 17434448
42. Discussion of DMP1 role in the maturation of odontoblasts and osteoblasts as well as in mineralization; identification of DMP1 mutations in autosomal-recessive hypophosphatemic rickets; and regulation of phosphate homeostasis through FGF23 [review]. PMID: 18037646
43. mRNA of DMP1 involved in the pathogenesis of hypophosphataemic rickets is highly expressed in cells of the osteoblasts/osteocyte lineage. PMID: 18214537
44. inactivating mutations in DMP1 increase, through yet unknown mechanisms, FGF23 synthesis and thus enhance renal phosphate excretion--REVIEW PMID: 18660670
45. binding of DMP1 with GRP-78 receptor might be an important mechanism by which DMP1 is internalized and transported to the nucleus during bone and tooth development PMID: 18757373
46. Dentin matrix protein-1 isoforms promote differential cell attachment and migration PMID: 18819913
47. A novel DMP1 deletion is identified as the cause of autosomal recessive hypophosphatemic rickets, as well as demonstrated that the ARHR mutations alter DMP1 cellular processing, and that DMP1 can be regulated by vitamin D. PMID: 19007919
48. Deletion of mouse Dmp1 results in bone hypomineralization. PMID: 16294270
49. DMP1 is expressed in salivary gland ducts. PMID: 15329369
50. DMP1 is expressed in parietal cells of Bowman's capsule and throughout the ductal system of nephrons. PMID: 15954904
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相關疾病：

Hypophosphatemic rickets, autosomal recessive, 1 (ARHR1)
亞細胞定位：

Nucleus. Cytoplasm. Secreted, extracellular space, extracellular matrix. Note=In proliferating preosteoblasts it is nuclear, during early maturation stage is cytoplasmic and in mature osteoblast localizes in the mineralized matrix. Export from the nucleus of differentiating osteoblast is triggered by the release of calcium from intracellular stores followed by a massive influx of this pool of calcium into the nucleus.
組織特異性：

Expressed in tooth particularly in odontoblast, ameloblast and cementoblast.
數(shù)據(jù)庫鏈接：

HGNC: 2932

OMIM: 241520

KEGG: hsa:1758

STRING: 9606.ENSP00000340935

UniGene: Hs.652366