Recombinant Human Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial (ALDH4A1)

中文名稱：

Recombinant Human Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial(ALDH4A1)
貨號：

CSB-YP001576HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Human Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial(ALDH4A1)
貨號：

CSB-EP001576HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Human Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial(ALDH4A1)
貨號：

CSB-EP001576HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Human Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial(ALDH4A1)
貨號：

CSB-BP001576HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Human Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial(ALDH4A1)
貨號：

CSB-MP001576HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

ALDH4A1
Uniprot No.：

P30038
別名：

AL4A1_HUMAN; aldehyde dehydrogenase 4; aldehyde dehydrogenase 4 family; member A1; Aldehyde dehydrogenase family 4 member A1; Aldehyde dehydrogenase; family 4; subfamily A; member 1; ALDH4; aldh4a1; Delta 1 pyrroline 5 carboxylate dehydrogenase; mitochondrial; Delta-1-pyrroline-5-carboxylate dehydrogenase; L-glutamate gamma-semialdehyde dehydrogenase; mitochondrial; mitochondrial delta-1-pyrroline 5-carboxylate dehydrogenase; P5C dehydrogenase; P5CD; P5CDh; P5CDhL; P5CDhS; Pyrroline-5-carboxylate dehydrogenase; RP11 128M10.1
種屬：

Homo sapiens (Human)
蛋白長度：

Full Length of Mature Protein
表達區域：

25-563
氨基酸序列

KHTSSL KVANEPVLAF TQGSPERDAL QKALKDLKGR MEAIPCVVGD EEVWTSDVQY QVSPFNHGHK VAKFCYADKS LLNKAIEAAL AARKEWDLKP IADRAQIFLK AADMLSGPRR AEILAKTMVG QGKTVIQAEI DAAAELIDFF RFNAKYAVEL EGQQPISVPP STNSTVYRGL EGFVAAISPF NFTAIGGNLA GAPALMGNVV LWKPSDTAML ASYAVYRILR EAGLPPNIIQ FVPADGPLFG DTVTSSEHLC GINFTGSVPT FKHLWKQVAQ NLDRFHTFPR LAGECGGKNF HFVHRSADVE SVVSGTLRSA FEYGGQKCSA CSRLYVPHSL WPQIKGRLLE EHSRIKVGDP AEDFGTFFSA VIDAKSFARI KKWLEHARSS PSLTILAGGK CDDSVGYFVE PCIVESKDPQ EPIMKEEIFG PVLSVYVYPD DKYKETLQLV DSTTSYGLTG AVFSQDKDVV QEATKVLRNA AGNFYINDKS TGSIVGQQPF GGARASGTND KPGGPHYILR WTSPQVIKET HKPLGDWSYA YMQ
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes.
基因功能參考文獻：
1. the impact of the hyperprolinemia-associated mutation of Ser352 to Leu on the structure and catalytic properties of the P5CDH PMID: 22516612
2. ALDH4 is a p53-inducible gene with a protective role in cellular stresses PMID: 14986171
3. ALDH4 is transcriptionally induced by p53. PMID: 14986171
相關疾病：

Hyperprolinemia 2 (HYRPRO2)
亞細胞定位：

Mitochondrion matrix.
蛋白家族：

Aldehyde dehydrogenase family
組織特異性：

Highest expression is found in liver followed by skeletal muscle, kidney, heart, brain, placenta, lung and pancreas.
數據庫鏈接：

HGNC: 406

OMIM: 239510

KEGG: hsa:8659

STRING: 9606.ENSP00000290597

UniGene: Hs.77448