Recombinant Human Cyclic AMP-responsive element-binding protein 3-like protein 3 (CREB3L3), partial

中文名稱：

Recombinant Human Cyclic AMP-responsive element-binding protein 3-like protein 3(CREB3L3),partial
貨號(hào)：

CSB-YP715009HU
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

Recombinant Human Cyclic AMP-responsive element-binding protein 3-like protein 3(CREB3L3),partial
貨號(hào)：

CSB-EP715009HU
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
其他：

中文名稱：

Recombinant Human Cyclic AMP-responsive element-binding protein 3-like protein 3(CREB3L3),partial
貨號(hào)：

CSB-EP715009HU-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Human Cyclic AMP-responsive element-binding protein 3-like protein 3(CREB3L3),partial
貨號(hào)：

CSB-BP715009HU
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Human Cyclic AMP-responsive element-binding protein 3-like protein 3(CREB3L3),partial
貨號(hào)：

CSB-MP715009HU
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

CREB3L3
Uniprot No.：

Q68CJ9
別名：

CREB3L3; CREBH; HYST1481Cyclic AMP-responsive element-binding protein 3-like protein 3; cAMP-responsive element-binding protein 3-like protein 3; Transcription factor CREB-H) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3-like protein 3]
種屬：

Homo sapiens (Human)
蛋白長(zhǎng)度：

Partial
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Transcription factor that may act during endoplasmic reticulum stress by activating unfolded protein response target genes. Activated in response to cAMP stimulation. In vitro, binds to the cAMP response element (CRE) and box-B element. Activates transcription through box-B element. Activates transcription through CRE. May function synergistically with ATF6. In acute inflammatory response, may activate expression of acute phase response (APR) genes. May be involved in growth suppression. Regulates FGF21 transcription.
基因功能參考文獻(xiàn)：
1. CREBH has a crucial role in glucose and lipid metabolism in the liver and small intestine. PMID: 29738435
2. Beta-TrCP controls ubiquitination and degradation of liver-enriched transcription factor CREB-H. PMID: 27029215
3. Identify a novel pathogenic mutation in CREB3L3 gene in a family with dominant hypertriglyceridemia with a variable pattern of penetrance. PMID: 26427795
4. CREBH activated by HBx interacted with HBx protein, leading to a synergistic effect on the expression of AP-1 target genes and the proliferation of hepatocellular carcinoma cells and mouse primary hepatocytes. PMID: 25428452
5. Taken together, our results demonstrated that human APOA5 is directly regulated by CREBH via CREBHRE and provided a new insight into the role of this liver-specific bZIP transcription factor in lipoprotein metabolism and triglyceride homeostasis PMID: 23957007
6. Studies indicate that mutations in CREB3L3 in individuals with extreme hypertriglyceridemia. PMID: 22262056
7. a novel mechanism of action of activated CB1R signaling to induce hepatic gluconeogenesis via direct activation of CREBH PMID: 21693703
8. Levels of CREB transcripts did NOT significantly differ in the thyroid adenomas and surrounding normal tissues. PMID: 12039695
9. analysis of CREB-H trafficking into alternate pathways of ERAD and stress-regulated intramembrane proteolysis PMID: 17875199
10. findings show that CREBH an endoplasmic reticulum stress-activated transcription factor, binds to and transactivates the hepcidin promoter PMID: 19679815
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亞細(xì)胞定位：

Endoplasmic reticulum membrane; Single-pass type II membrane protein.; [Processed cyclic AMP-responsive element-binding protein 3-like protein 3]: Nucleus. Note=Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus.
蛋白家族：

BZIP family, ATF subfamily
組織特異性：

Exclusively expressed in liver. Underexpressed in hepatocellular carcinoma tissues.
數(shù)據(jù)庫(kù)鏈接：

HGNC: 18855

OMIM: 611998

KEGG: hsa:84699

STRING: 9606.ENSP00000078445

UniGene: Hs.247744