Recombinant Human Conserved oligomeric Golgi complex subunit 7 (COG7)

中文名稱：

Recombinant Human Conserved oligomeric Golgi complex subunit 7(COG7)
貨號：

CSB-YP005711HU
規(guī)格：
來源：

Yeast
其他：

中文名稱：

Recombinant Human Conserved oligomeric Golgi complex subunit 7(COG7)
貨號：

CSB-EP005711HU
規(guī)格：
來源：

E.coli
其他：

中文名稱：

Recombinant Human Conserved oligomeric Golgi complex subunit 7(COG7)
貨號：

CSB-EP005711HU-B
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Human Conserved oligomeric Golgi complex subunit 7(COG7)
貨號：

CSB-BP005711HU
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Human Conserved oligomeric Golgi complex subunit 7(COG7)
貨號：

CSB-MP005711HU
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

COG7
Uniprot No.：

P83436
別名：

CDG2E; COG complex subunit 7; cog7; COG7_HUMAN; Component of oligomeric Golgi complex 7; Conserved oligomeric Golgi complex component 7; Conserved oligomeric Golgi complex subunit 7
種屬：

Homo sapiens (Human)
蛋白長度：

Full length protein
表達區(qū)域：

1-770
氨基酸序列

MDFSKFLADD FDVKEWINAA FRAGSKEAAS GKADGHAATL VMKLQLFIQE VNHAVEETSH QALQNMPKVL RDVEALKQEA SFLKEQMILV KEDIKKFEQD TSQSMQVLVE IDQVKSRMQL AAESLQEADK WSTLSADIEE TFKTQDIAVI SAKLTGMQNS LMMLVDTPDY SEKCVHLEAL KNRLEALASP QIVAAFTSQA VDQSKVFVKV FTEIDRMPQL LAYYYKCHKV QLLAAWQELC QSDLSLDRQL TGLYDALLGA WHTQIQWATQ VFQKPHEVVM VLLIQTLGAL MPSLPSCLSN GVERAGPEQE LTRLLEFYDA TAHFAKGLEM ALLPHLHEHN LVKVTELVDA VYDPYKPYQL KYGDMEESNL LIQMSAVPLE HGEVIDCVQE LSHSVNKLFG LASAAVDRCV RFTNGLGTCG LLSALKSLFA KYVSDFTSTL QSIRKKCKLD HIPPNSLFQE DWTAFQNSIR IIATCGELLR HCGDFEQQLA NRILSTAGKY LSDSCSPRSL AGFQESILTD KKNSAKNPWQ EYNYLQKDNP AEYASLMEIL YTLKEKGSSN HNLLAAPRAA LTRLNQQAHQ LAFDSVFLRI KQQLLLISKM DSWNTAGIGE TLTDELPAFS LTPLEYISNI GQYIMSLPLN LEPFVTQEDS ALELALHAGK LPFPPEQGDE LPELDNMADN WLGSIARATM QTYCDAILQI PELSPHSAKQ LATDIDYLIN VMDALGLQPS RTLQHIVTLL KTRPEDYRQV SKGLPRRLAT TVATMRSVNY
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Required for normal Golgi function.
基因功能參考文獻：
1. Cog5-Cog7 crystal structure reveals interactions essential for the function of a multisubunit tethering complex. PMID: 25331899
2. COG5- and COG7 subunits play distinctive roles in controlling Golgi structure and function PMID: 16051600
3. Retrograde transport of multiple Golgi proteins to the ER in COG-7-deficient patient fibroblasts via brefeldin A-induced tubules was significantly slower than occurs in normal fibroblasts. PMID: 16510524
4. A homozygous, intronic splice site mutation (c.169+4A>C) of the COG7 gene was identified in 3 patients with Congenital Disorder of Glycosylation type IIe. PMID: 17356545
5. A new mutation in COG7 extends the spectrum of COG subunit deficiencies. PMID: 19577670
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相關(guān)疾病：

Congenital disorder of glycosylation 2E (CDG2E)
亞細胞定位：

Golgi apparatus membrane; Peripheral membrane protein.
蛋白家族：

COG7 family
數(shù)據(jù)庫鏈接：

HGNC: 18622

OMIM: 606978

KEGG: hsa:91949

STRING: 9606.ENSP00000305442

UniGene: Hs.185807