Recombinant Human Connector enhancer of kinase suppressor of ras 2 (CNKSR2), partial

文獻引用 (1)

中文名稱：

Recombinant Human Connector enhancer of kinase suppressor of ras 2(CNKSR2),partial
貨號：

CSB-YP005653HU
說明書：

MSDS Datasheet
規(guī)格：

￥1500
圖片：
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
其他：

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純度：

Greater than 90% as determined by SDS-PAGE.
基因名：

CNKSR2
Uniprot No.：

Q8WXI2
別名：

CNKSR2; CNK2; KIAA0902; KSR2Connector enhancer of kinase suppressor of ras 2; Connector enhancer of KSR 2; CNK homolog protein 2; CNK2
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
來源：

Yeast
分子量：

19.1kDa
表達區(qū)域：

650-800aa
氨基酸序列

AAEHLDDMNRWLNRINMLTAGYAERERIKQEQDYWSESDKEEADTPSTPKQDSPPPPYDTYPRPPSMSCASPYVEAKHSRLSSTETSQSQSSHEEFRQEVTGSSAVSPIRKTASQRRSWQDLIETPLTSSGLHYLQTLPLEDSVFSDSAAI
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 6xHis-tagged
產(chǎn)品提供形式：

Liquid or Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

引用文獻

Regulation of CNKSR2 protein stability by the HECT E3 ubiquitin ligase Smurf2, and its role in breast cancer progression David D.et al,BMC Cancer,2018

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功能：

May function as an adapter protein or regulator of Ras signaling pathways.
基因功能參考文獻：
1. High CNKSR2 expression is associated with breast cancer progression. PMID: 29534682
2. CNKSR2 deletions: a novel cause of X-linked intellectual disability and seizures. PMID: 25754917
3. This study describes the phenotype of CNKSR2 deficiency and its involvement in systems underlying common neurological PMID: 25223753
4. CNK2 through interaction with Raf and Rlf may function as a regulator of Ras signaling. PMID: 14597674
5. CNK and HYP form a discrete dimer by their SAM domains to mediate RAF kinase signaling. PMID: 18287031
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亞細胞定位：

Cytoplasm. Membrane; Peripheral membrane protein.
蛋白家族：

CNKSR family
數(shù)據(jù)庫鏈接：

HGNC: 19701

OMIM: 300724

KEGG: hsa:22866

STRING: 9606.ENSP00000368824

UniGene: Hs.555917