Recombinant Human Class A basic helix-loop-helix protein 15 (BHLHA15)

中文名稱：

Recombinant Human Class A basic helix-loop-helix protein 15(BHLHA15)
貨號：

CSB-YP755911HU
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Human Class A basic helix-loop-helix protein 15(BHLHA15)
貨號：

CSB-EP755911HU
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Human Class A basic helix-loop-helix protein 15(BHLHA15)
貨號：

CSB-EP755911HU-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Human Class A basic helix-loop-helix protein 15(BHLHA15)
貨號：

CSB-BP755911HU
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Human Class A basic helix-loop-helix protein 15(BHLHA15)
貨號：

CSB-MP755911HU
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

BHLHA15
Uniprot No.：

Q7RTS1
別名：

Basic helix loop helix domain containing class B 8; Basic helix loop helix family member a15; BHA15_HUMAN; Bhlha15; bHLHB8; Class A basic helix-loop-helix protein 15; Class B basic helix-loop-helix protein 8; Class II bHLH protein MIST1; intestine and stomach expression 1; MIST 1; MIST-1; MIST1; Muscle; Muscle intestine and stomach expression 1; protein MIST1
種屬：

Homo sapiens (Human)
蛋白長度：

full length protein
表達區域：

1-189
氨基酸序列

MKTKNRPPRR RAPVQDTEAT PGEGTPDGSL PNPGPEPAKG LRSRPARAAA RAPGEGRRRR PGPSGPGGRR DSSIQRRLES NERERQRMHK LNNAFQALRE VIPHVRADKK LSKIETLTLA KNYIKSLTAT ILTMSSSRLP GLEGPGPKLY QHYQQQQQVA GGALGATEAQ PQGHLQRYST QIHSFREGT
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Plays a role in controlling the transcriptional activity of MYOD1, ensuring that expanding myoblast populations remain undifferentiated. Repression may occur through muscle-specific E-box occupancy by homodimers. May also negatively regulate bHLH-mediated transcription through an N-terminal repressor domain. Serves as a key regulator of acinar cell function, stability, and identity. Also required for normal organelle localization in exocrine cells and for mitochondrial calcium ion transport. May function as a unique regulator of gene expression in several different embryonic and postnatal cell lineages. Binds to the E-box consensus sequence 5'-CANNTG-3'.
基因功能參考文獻：
1. noted a higher mean value of microvascular density in CK5/6 and Ep-CAM-immunopositive tumors, carcinomas with aberrant CK8/18 expression, and carcinomas with no or strong expression of MMP-2 in stromal fibroblast-like cells PMID: 22495370
2. Activation of protein kinase Cdelta leads to increased pancreatic acinar cell dedifferentiation in the absence of MIST1. PMID: 22374815
3. Chief cells emerge from the Mist. PMID: 21907708
4. MIST1 is enriched upon plasma cell differentiation. PMID: 21098683
5. Our findings implicate MIST1 as a reliable marker of mature, healthy chief cells, and we provide the first evidence that metaplasia in humans arises at least in part from the chief cell lineage. PMID: 20709804
6. MIST1 binds to highly conserved CATATG E-boxes to directly activate transcription of 6 genes, including those encoding the small GTPases RAB26 and RAB3D. PMID: 20038531
7. Mist1 within the hierarchy of known helix-loop-helix/basic helix-loop-helix proteins that control mammary epithelial cell development PMID: 16645041
顯示更多

收起更多
亞細胞定位：

Nucleus.
組織特異性：

Expressed in brain, liver, spleen and skeletal muscle.
數據庫鏈接：

HGNC: 22265

OMIM: 608606

KEGG: hsa:168620

STRING: 9606.ENSP00000326391

UniGene: Hs.511979