Recombinant Human Chymotrypsin-like elastase family member 1 (CELA1)

中文名稱：

Recombinant Human Chymotrypsin-like elastase family member 1(CELA1)
貨號：

CSB-YP892481HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Human Chymotrypsin-like elastase family member 1(CELA1)
貨號：

CSB-EP892481HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Human Chymotrypsin-like elastase family member 1(CELA1)
貨號：

CSB-EP892481HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Human Chymotrypsin-like elastase family member 1(CELA1)
貨號：

CSB-BP892481HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Human Chymotrypsin-like elastase family member 1(CELA1)
貨號：

CSB-MP892481HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

CELA1
Uniprot No.：

Q9UNI1
別名：

CELA 1; CELA1; CELA1_HUMAN; Chymotrypsin like elastase family member 1; Chymotrypsin-like elastase family member 1; ELA1; Elastase 1; Elastase 1 pancreatic; Elastase-1; OTTHUMP00000236087
種屬：

Homo sapiens (Human)
蛋白長度：

Full Length of Mature Protein
表達區域：

19-258
氨基酸序列

VV GGTEAGRNSW PSQISLQYRS GGSRYHTCGG TLIRQNWVMT AAHCVDYQKT FRVVAGDHNL SQNDGTEQYV SVQKIVVHPY WNSDNVAAGY DIALLRLAQS VTLNSYVQLG VLPQEGAILA NNSPCYITGW GKTKTNGQLA QTLQQAYLPS VDYAICSSSS YWGSTVKNTM VCAGGDGVRS GCQGDSGGPL HCLVNGKYSV HGVTSFVSSR GCNVSRKPTV FTQVSAYISW INNVIASN
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Acts upon elastin.
基因功能參考文獻：
1. Results show that fecal elastase 1 (FE1) fails to detect steatorrhea in patients with locally advanced pancreatic cancer (LAPC) and is an inappropriate marker of exocrine pancreatic insufficiency in daily clinical practice. PMID: 29521945
2. A heterozygous frameshift variant c.419delC in exons of the CELA1 gene identified in all punctate palmoplantar keratoderma patients. PMID: 28604957
3. Inverse association of HbA1c with faecal elastase 1 in people without diabetes suggests that pancreatic exocrine dysfunction might be an early disturbance that develops in parallel with hyperglycemia. PMID: 26601880
4. Results indicate that the extract of the mycelium of Tricholoma matsutake decreased elastase activity in a dose-dependent manner and reduced the levels of matrix metalloproteinase 1 (MMP-1). PMID: 25319362
5. Mutant genes (CELA1, HSPG2, and KCNK5) in Balkan endemic nephropathy patients encode proteins involved in basement membrane/extracellular matrix and vascular tone, tightly connected to process of angiogenesis. PMID: 24949484
6. Data indicate that fecal elastase-1 was lower in the pancreaticoduodenectomy (PD) group. PMID: 24622077
7. Fecal elastase-1 is useful to identify pancreatic insufficiency. Steatorrhea is anticipated in non-operated patients only when FE-1 is below the limit for a confident measurement of our assay PMID: 23395568
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亞細胞定位：

Secreted.
蛋白家族：

Peptidase S1 family, Elastase subfamily
組織特異性：

Basal layers of epidermis (at protein level). Not expressed in the pancreas.
數據庫鏈接：

HGNC: 3308

OMIM: 130120

KEGG: hsa:1990

STRING: 9606.ENSP00000293636

UniGene: Hs.348395