Recombinant Human Chordin (CHRD), partial

中文名稱：

Recombinant Human Chordin(CHRD) ,partial
貨號：

CSB-YP005377HU
規(guī)格：
來源：

Yeast
其他：

中文名稱：

Recombinant Human Chordin(CHRD) ,partial
貨號：

CSB-EP005377HU
規(guī)格：
來源：

E.coli
其他：

中文名稱：

Recombinant Human Chordin(CHRD) ,partial
貨號：

CSB-EP005377HU-B
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Human Chordin(CHRD) ,partial
貨號：

CSB-BP005377HU
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Human Chordin(CHRD) ,partial
貨號：

CSB-MP005377HU
規(guī)格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

CHRD
Uniprot No.：

Q9H2X0
別名：

CHRD; UNQ217/PRO243Chordin
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.
基因功能參考文獻：
1. Data suggest CHRD (chordin) cleavage by tolloid-like metalloproteinases is insufficient to regulate BMP(bone morphogenetic protein)/BMPR signaling; CHRD fragments and TSG (twisted gastrulation protein) contribute to inhibition of BMP/BMPR signaling. PMID: 26517884
2. C-terminal chordin domains play an important role in Bone morphogenetic protein regulation. PMID: 25157165
3. chordin silencing increased osteogenic differentiation without supplemented BMP-2. PMID: 23931154
4. results suggest that CHRD could participate in regulating BMP activity in normal ovarian surface epithelium physiology, and that its mis-expression in ovarian surface epithelium may facilitate cancer incidence and/or progression PMID: 16449796
5. Bone morphogenetic protein (BMP) chordin is produced endogenously during osteogenic differentiation of human mesenchymal stem cells (MSCs); blockade of bone morphogenetic inhibitor chordin increases the rate of osteogenic differentiation of MSCs in vitro. PMID: 18533030
6. Noggin and chordin were also expressed most intensely in areas of cartilage formation and there was no difference in their expression between the non-hypertrophic and hypertrophic chondrocytes. PMID: 19023570
7. there was no difference in the expression of the noggin and chordin between healing and nonhealing fractures PMID: 19058174
8. Alternatively spliced variants have different patterns of expression to influence BMP activity in varying physiolgical situations. PMID: 11472837
顯示更多

收起更多
亞細胞定位：

Secreted.
蛋白家族：

Chordin family
組織特異性：

Expressed at the highest level in liver.
數據庫鏈接：

HGNC: 1949

OMIM: 603475

KEGG: hsa:8646

STRING: 9606.ENSP00000204604

UniGene: Hs.166186