Recombinant Human Chondroitin sulfate N-acetylgalactosaminyltransferase 1 (CSGALNACT1), partial

中文名稱：

Recombinant Human Chondroitin sulfate N-acetylgalactosaminyltransferase 1(CSGALNACT1),partial
貨號：

CSB-YP006051HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Human Chondroitin sulfate N-acetylgalactosaminyltransferase 1(CSGALNACT1),partial
貨號：

CSB-EP006051HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Human Chondroitin sulfate N-acetylgalactosaminyltransferase 1(CSGALNACT1),partial
貨號：

CSB-EP006051HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Human Chondroitin sulfate N-acetylgalactosaminyltransferase 1(CSGALNACT1),partial
貨號：

CSB-BP006051HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Human Chondroitin sulfate N-acetylgalactosaminyltransferase 1(CSGALNACT1),partial
貨號：

CSB-MP006051HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

CSGALNACT1
Uniprot No.：

Q8TDX6
別名：

4-N-acetylgalactosaminyltransferase 1; Beta4GalNAcT 1; beta4GalNAcT; Beta4GalNAcT-1; Beta4GalNAcT1; CGAT1_HUMAN; ChGn; Chondroitin beta-1; Chondroitin beta1 4 N acetylgalactosaminyltransferase; Chondroitin beta1 4 N acetylgalactosaminyltransferase 1; Chondroitin sulfate N acetylgalactosaminyltransferase 1; Chondroitin sulfate N-acetylgalactosaminyltransferase 1; CSGalNAcT 1; CsGalNAcT-1; Csgalnact1; FLJ11264; FLJ13760
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of glucuronic acid (GlcUA). Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains. Important role in chondroitin chain biosynthesis in cartilage formation and subsequent endochondral ossification. Moreover, is involved in the metabolism of aggrecan.
基因功能參考文獻：
1. In men, patients who had multiple sclerosis (MS) with S126L had a slower disease progression. This cSNP might be associated with the sex differences in clinical course of MS. PMID: 26806424
2. CSGalNAcT-1 and Hapln-1 may play important roles in the pathogenesis of Kashin-Beck disease and osteoarthritis. PMID: 23748413
3. CSGalNAcT-1 exhibited higher enzymatic efficiency toward monosulfated trisaccharides substituted at C4 or C6 position of Gal1, and at C6 of Gal2 compared with the unsulfated oligosaccharide. PMID: 22156920
4. CSGALNACT1 missense mutations are associated with neuropathies. PMID: 21160489
5. higher expression in the fetal skin than in adult skin PMID: 19701759
6. These results suggest that this enzyme has N-acetylgalactosaminyltransferase activity in both the elongation and initiation of chondroitin sulfate synthesis. PMID: 12163485
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亞細胞定位：

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.
蛋白家族：

Chondroitin N-acetylgalactosaminyltransferase family
組織特異性：

Ubiquitous, with the highest levels in placenta, thyroid, bladder, prostate and adrenal gland. Detected at low levels in the other tissues examined.
數據庫鏈接：

HGNC: 24290

OMIM: 616615

KEGG: hsa:55790

STRING: 9606.ENSP00000310891

UniGene: Hs.613729