Recombinant Human Baculoviral IAP repeat-containing protein 8 (BIRC8)

中文名稱：

Recombinant Human Baculoviral IAP repeat-containing protein 8(BIRC8)
貨號：

CSB-EP846680HU
說明書：

MSDS Datasheet
規(guī)格：

￥1836
圖片：
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

Greater than 90% as determined by SDS-PAGE.
基因名：

BIRC8
Uniprot No.：

Q96P09
別名：

Baculoviral IAP repeat containing 8; Baculoviral IAP repeat containing protein 8; Baculoviral IAP repeat-containing protein 8; BIRC 8; BIRC8; BIRC8 protein; BIRC8_HUMAN; hILP 2; hILP2; IAP like protein 2; IAP-like protein 2; ILP 2; ILP-2; Inhibitor of apoptosis like protein 2; Inhibitor of apoptosis-like protein 2; Testis specific inhibitor of apoptosis; Testis-specific inhibitor of apoptosis
種屬：

Homo sapiens (Human)
蛋白長度：

Full Length of BC039318
來源：

E.coli
分子量：

54.1kDa
表達(dá)區(qū)域：

1-236aa
氨基酸序列

MTGYEARLITFGTWMYSVNKEQLARAGFYAIGQEDKVQCFHCGGGLANWKPKEDPWEQHAKWYPGCKYLLEEKGHEYINNIHLTRSLEGALVQTTKKTPSLTKRISDTIFPNPMLQEAIRMGFDFKDVKKIMEERIQTSGSNYKTLGVLVADLVSAQKDTTENELNQTSLQREISPEEPLRRLQEEKLCKICMDRHIAVVFIPCGHLVTCKQCAEAVDRCPMCSMVIDFKQRVFMS
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標(biāo)簽：

N-terminal GST-tagged
產(chǎn)品提供形式：

Liquid or Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產(chǎn)品評價

靶點(diǎn)詳情

功能：

Protects against apoptosis mediated by BAX.
基因功能參考文獻(xiàn)：
1. High ILP-2 expression is associated with breast cancer. PMID: 30106449
2. Fumonisin B1 caused dose-dependent increase in BIRC-8/ILP-2 mRNA and protein expression in HepG2 cells to inhibit apoptosis. PMID: 25800559
3. results indicate that ILP-2 is a novel breast cancer biomarker in the peripheral blood. PMID: 23222679
4. increased expression with progression of chronic myeloid leukaemia PMID: 24266799
5. role in preventing shear-stress induced endothelial cell apoptosis via negative regulation of caspase-3 PMID: 12372615
6. ILP2 is an unstable protein, and cannot inhibit caspase 9 in a physiological way on its own; possibly ILP2 requires assistance from unidentified cellular factors to be an effective inhibitor of apoptosis in vivo PMID: 15485395
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亞細(xì)胞定位：

Cytoplasm.
蛋白家族：

IAP family
組織特異性：

Testis specific in normal tissues.
數(shù)據(jù)庫鏈接：

HGNC: 14878

KEGG: hsa:112401

STRING: 9606.ENSP00000412957

UniGene: Hs.348263