Recombinant Human Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 (AGAP1), partial

中文名稱：

Recombinant Human Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1(AGAP1) ,partial
貨號(hào)：

CSB-YP890774HU
規(guī)格：
來源：

Yeast
其他：

中文名稱：

Recombinant Human Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1(AGAP1) ,partial
貨號(hào)：

CSB-EP890774HU
規(guī)格：
來源：

E.coli
其他：

中文名稱：

Recombinant Human Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1(AGAP1) ,partial
貨號(hào)：

CSB-EP890774HU-B
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Human Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1(AGAP1) ,partial
貨號(hào)：

CSB-BP890774HU
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Human Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1(AGAP1) ,partial
貨號(hào)：

CSB-MP890774HU
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

AGAP1
Uniprot No.：

Q9UPQ3
別名：

AGAP 1; AGAP-1; Agap1; AGAP1_HUMAN; Arf GAP with GTP binding proteinlike ANK repeat and PH domains 1; Arf-GAP with GTPase; ANK repeat and PH domain-containing protein 1; ArfGAP with GTPase domain ankyrin repeat and PH domain 1; Centaurin gamma 2; Centaurin-gamma-2; CENTG2; Cnt-g2; GGAP 1; GGAP1; GTP binding and GTPase activating protein 1; GTP-binding and GTPase-activating protein 1; KIAA1099; MGC71657
種屬：

Homo sapiens (Human)
蛋白長(zhǎng)度：

Partial
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

GTPase-activating protein for ARF1 and, to a lesser extent, ARF5. Directly and specifically regulates the adapter protein 3 (AP-3)-dependent trafficking of proteins in the endosomal-lysosomal system.
基因功能參考文獻(xiàn)：
1. The effect of AGAP1 Knockdown could be rescued by FLAG-AGAP1, but not by an AGAP1 mutant that did not bind Kif2A efficiently, ArfGAP1-HA or Kif2A-GFP. The results support the hypothesis that the Kif2A.AGAP1 complex contributes to control of cytoskeleton remodeling involved in cell movement. PMID: 27531749
2. GTP-binding protein-like domain of AGAP1 is protein binding site that allosterically regulates ArfGAP protein catalytic activity. PMID: 22453919
3. overexpression inhibited formation of platelet-derived growth factor-induced ruffles and also induced loss of actin stress fibers PMID: 12388557
4. AGAP1 is a novel binding partner of nitric oxide-sensitive guanylyl cyclase PMID: 15381706
5. CENTG2 is an intriguing candidate gene that merits further scrutiny for its role in autism. PMID: 15892143
6. The AGAP1 has been found to associate with the adaptor protein complex AP-3 and regulate the function of AP-3 endosomes. PMID: 16079295
7. AGAP1 is unique among the AZAPs in its specificity for Arf1, and this activity is dependent on its NH(2)-terminal GTPase-like domain. AGAP1 induce reciprocal activation of Arf6. PMID: 18003747
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亞細(xì)胞定位：

Cytoplasm. Note=Associates with the endocytic compartment.
蛋白家族：

Centaurin gamma-like family
組織特異性：

Widely expressed.
數(shù)據(jù)庫(kù)鏈接：

HGNC: 16922

OMIM: 608651

KEGG: hsa:116987

STRING: 9606.ENSP00000307634

UniGene: Hs.435039