Recombinant Human Activity-dependent neuroprotector homeobox protein (ADNP), partial

中文名稱：

Recombinant Human Activity-dependent neuroprotector homeobox protein(ADNP) ,partial
貨號：

CSB-YP887964HU
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Human Activity-dependent neuroprotector homeobox protein(ADNP) ,partial
貨號：

CSB-EP887964HU
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Human Activity-dependent neuroprotector homeobox protein(ADNP) ,partial
貨號：

CSB-EP887964HU-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Human Activity-dependent neuroprotector homeobox protein(ADNP) ,partial
貨號：

CSB-BP887964HU
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Human Activity-dependent neuroprotector homeobox protein(ADNP) ,partial
貨號：

CSB-MP887964HU
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

ADNP
Uniprot No.：

Q9H2P0
別名：

Activity dependent neuroprotective protein; Activity dependent neuroprotector ; Activity-dependent neuroprotective protein; Activity-dependent neuroprotector homeobox protein; Adnp; ADNP_HUMAN; KIAA0784
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Potential transcription factor. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation.
基因功能參考文獻：
1. in patients with intellectual disability, autism spectrum disorder and features suggestive of Noonan syndrome should have DNA analysis for the ADNP gene if the Noonan syndrome panel failed to identify a specific mutation. PMID: 29424797
2. The role of ADNP in autophagy, and in autism, schizophrenia and Alzheimer's disease is described. PMID: 28940660
3. Our findings indicate that ADNP is a tumor suppressor and promising prognostic marker, and that ketamine treatment with ADNP induction is a potential therapeutic approach that may add benefit to current treatment protocols for patients with colorectal cancer PMID: 27903678
4. From a clinical standpoint, a differential diagnosis of patients with blepharophimosis should include ADNP mutations in addition to blepharophimosis ptosis epicanthus inversus syndrome, especially when intellectual disability is present PMID: 28407407
5. The parents of 44/54 ADNP-mutated children reported an almost full erupted dentition by 1 year of age, including molars and only 10 of the children had teeth within the normal developmental time range. PMID: 28221363
6. SHANK3, CHD8, and ADNP had distinctly higher scores than all other genes in the dataset describing the genes associated with autism spectrum disorders. PMID: 27790361
7. The study identified intratumoral heterogeneity (ITH) of the ADNP mutations in colorectal cancers, suggesting that ADNP mutations occurred during tumor progression rather than as an early event. The generation of ITH may influence on clinical outcome of the cancer patients. PMID: 27308845
8. These findings demonstrate that the down-regulation of protein ADNP is an early pathological alteration and may contribute to dopaminergic neurodegeneration in Parkinson's disease PMID: 27003787
9. This review covers the myriad of important ADNP-protein interactions and glimpse at their potential meaning in autism, schizophrenia and Alzheimer's disease. [review] PMID: 25955282
10. ADNP expression was increased in male hippocampus samples compared to female samples. PMID: 25646590
11. Mutations in the ADNP gene cause syndromic autism.Ample evidence exists that ADNP is of key importance for proper functioning of the nBAF complex. PMID: 25169753
12. This study showed ADNP that deregulated in postmortem hippocampal samples from schizophrenia patients, but that now showed a significantly increased expression in lymphocytes from related patients. PMID: 24365867
13. Ten patients with autism spectrum disorders and other shared clinical characteristics, including intellectual disability and facial dysmorphisms caused by a mutation in ADNP, a transcription factor involved in the SWI/SNF remodeling complex. PMID: 24531329
14. Chromatin immunoprecipitation demonstrates the ability of ADNP to bind to its own promoter, consistent with its action as a repressor of both promoter-supported and endogenous ADNP expression. PMID: 21647709
15. Our results suggested that ADNP may play an important role in slowing the progression of clinical symptoms of AD. PMID: 22554909
16. ADNP is expressed in many immune system cells. ADNP mRNA is reduced in PBMCs in MS. The peptide NAP, which plays an important role in neuroprotection, has potential immunomodulatory properties. PMID: 19923857
17. Activity-dependent neuroprotective protein constitutes a novel element in the SWI/SNF chromatin remodeling complex. PMID: 17878164
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相關疾病：

Helsmoortel-van der Aa syndrome (HVDAS)
亞細胞定位：

Nucleus.
組織特異性：

Widely expressed. Strong expression in heart, skeletal muscle, kidney and placenta. In brain, expression is stronger in the cerebellum and cortex regions. No expression detected in the colon. Strong increase of expression in colon and breast cancer tissue
數據庫鏈接：

HGNC: 15766

OMIM: 611386

KEGG: hsa:23394

STRING: 9606.ENSP00000342905

UniGene: Hs.293736