Recombinant Human AP-4 complex subunit mu-1 (AP4M1)

中文名稱：

Recombinant Human AP-4 complex subunit mu-1(AP4M1)
貨號：

CSB-YP001883HU
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Human AP-4 complex subunit mu-1(AP4M1)
貨號：

CSB-EP001883HU
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Human AP-4 complex subunit mu-1(AP4M1)
貨號：

CSB-EP001883HU-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Human AP-4 complex subunit mu-1(AP4M1)
貨號：

CSB-BP001883HU
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Human AP-4 complex subunit mu-1(AP4M1)
貨號：

CSB-MP001883HU
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

AP4M1
Uniprot No.：

O00189
別名：

Adapter-related protein complex 4 mu-1 subunit; Adaptor related protein complex 4 mu 1 subunit; Adaptor related protein complex AP 4 mu4 subunit; Adaptor related protein complex AP4 mu4 subunit; Adaptor-related protein complex AP-4; mu 1; AP 4 adapter complex mu subunit; AP 4 complex subunit mu 1; AP-4 adapter complex mu subunit; AP-4 complex subunit mu-1; AP4 adapter complex mu subunit; AP4 complex subunit mu 1; AP4M1; AP4M1_HUMAN; Ap4m4; CPSQ3; MU 4; Mu adaptin related protein 2; MU ARP2; Mu subunit of AP 4; Mu subunit of AP-4; Mu-adaptin-related protein 2; mu-ARP2; mu4; Mu4-adaptin; MUARP 2; MUARP2; SPG50
種屬：

Homo sapiens (Human)
蛋白長度：

Full length protein
表達區域：

1-453
氨基酸序列

MISQFFILSS KGDPLIYKDF RGDSGGRDVA ELFYRKLTGL PGDESPVVMH HHGRHFIHIR HSGLYLVVTT SENVSPFSLL ELLSRLATLL GDYCGSLGEG TISRNVALVY ELLDEVLDYG YVQTTSTEML RNFIQTEAVV SKPFSLFDLS SVGLFGAETQ QSKVAPSSAA SRPVLSSRSD QSQKNEVFLD VVERLSVLIA SNGSLLKVDV QGEIRLKSFL PSGSEMRIGL TEEFCVGKSE LRGYGPGIRV DEVSFHSSVN LDEFESHRIL RLQPPQGELT VMRYQLSDDL PSPLPFRLFP SVQWDRGSGR LQVYLKLRCD LLSKSQALNV RLHLPLPRGV VSLSQELSSP EQKAELAEGA LRWDLPRVQG GSQLSGLFQM DVPGPPGPPS HGLSTSASPL GLGPASLSFE LPRHTCSGLQ VRFLRLAFRP CGNANPHKWV RHLSHSDAYV IRI
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. Within AP-4, the mu-type subunit AP4M1 is directly involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos. The adaptor protein complex 4 (AP-4) may also recognize other types of sorting signal.
基因功能參考文獻：
1. analysis of the AP4M1 mutation associated with aggressive behavior in addition to mild dysmorphic features, intellectual disability, spastic paraparesis and reduced head circumference [case report] PMID: 25496299
2. Results show that AP-4 can bind different types of cytosolic signals known to mediate basolateral transport in epithelial cells. Depletion of mu 4 results in the mis-sorting of several proteins in epithelial cells. PMID: 11802162
3. AP-4 protein complex is involved in the regulation of somatodendritic-specific distribution of its cargo proteins including AMPA receptors. PMID: 18341993
4. In all five patients with autosomal-recessive type of tetraplegic cerebral palsy with mental retardation, a donor splice site pathogenic mutation in intron 14 of the AP4M1 gene (c.1137+1G-->T), was identified. PMID: 19559397
相關疾病：

Spastic paraplegia 50, autosomal recessive (SPG50)
亞細胞定位：

Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Early endosome.
蛋白家族：

Adaptor complexes medium subunit family
組織特異性：

Ubiquitous. Highly expressed in testis and lowly expressed in brain and lung.
數據庫鏈接：

HGNC: 574

OMIM: 602296

KEGG: hsa:9179

STRING: 9606.ENSP00000352603

UniGene: Hs.632317