Recombinant Epstein-Barr virus Apoptosis regulator BHRF1 (BHRF1), partial

中文名稱：

Recombinant Epstein-Barr virus Apoptosis regulator BHRF1 (BHRF1) ,partial
貨號：

CSB-YP314084EEZ1
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Epstein-Barr virus Apoptosis regulator BHRF1 (BHRF1) ,partial
貨號：

CSB-EP314084EEZ1
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Epstein-Barr virus Apoptosis regulator BHRF1 (BHRF1) ,partial
貨號：

CSB-EP314084EEZ1-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Epstein-Barr virus Apoptosis regulator BHRF1 (BHRF1) ,partial
貨號：

CSB-BP314084EEZ1
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Epstein-Barr virus Apoptosis regulator BHRF1 (BHRF1) ,partial
貨號：

CSB-MP314084EEZ1
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

BHRF1
Uniprot No.：

P0C6Z1
別名：

BHRF1; Apoptosis regulator BHRF1; Early antigen protein R; EA-R; Nuclear antigen
種屬：

Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Prevents premature death of the host cell during virus production, which would otherwise reduce the amount of progeny virus. Acts as a host B-cell leukemia/lymphoma 2 (Bcl-2) homolog, and interacts with pro-apoptotic proteins to prevent mitochondria permeabilization, release of cytochrome c and subsequent apoptosis of the host cell.
基因功能參考文獻：
1. The interaction between EBV-miR-BHRF1-2 and PRDM1 may be one of the mechanisms by which EBV-miRBHRF1-2 promotes Epstein-Barr virus lymphomagenesis. PMID: 26530011
2. 79V88V is the dominant variant in nasopharyngeal carcinoma and EBV-associated gastric carcinoma biopsies. PMID: 21114920
3. The authors report that Drosha cleavage of latency III BHRF1 RNA and cis-acting splicing effects inhibit splicing and inhibit BHRF1 RNA and protein expression. PMID: 21697496
4. in lymphoid cells, BHRF1 binds a selective sub-set of pro-apoptotic proteins (Bid, Puma, Bak) expressed by host cells. PMID: 21203485
5. viral miRNAs of the BHRF1 locus inhibit apoptosis and favor cell cycle progression and proliferation during the early phase of infected human primary B cells. PMID: 20808852
6. Results indicate that EBV is essential for the survival of Burkitt lymphoma cells and that BHRF1 functions as a survival factor, and imply a critical contribution of BHRF1 to the pathogenesis of Wp-restricted BLs. PMID: 20042495
7. killing of latently infected cells through the recognition of a protein produced during the lytic cycle is due to transfer of BHRF1 from lytically infected to latently infected cells, leading to their optimal recognition by BHRF1-specific CD4+ T cells PMID: 16339529
8. human VRK2 interacts specifically with EBV BHRF1 and that the interaction is involved in protecting cells from apoptosis PMID: 16963744
9. BHRF1 is constitutively expressed as a latent protein in growth-transformed cells in vitro and may contribute to virus-associated lymphomagenesis in vivo. PMID: 19283066
10. BHRF1 may act either by binding preferentially the most lethal form of Bim or by acting catalytically on Bim to block apoptosis. PMID: 19293378
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亞細胞定位：

Host membrane; Single-pass membrane protein. Host mitochondrion.
蛋白家族：

Bcl-2 family
數據庫鏈接：

KEGG: vg:3783706