Recombinant Drosophila melanogaster Protein extra-macrochaetae (emc)

中文名稱：

黑腹果蠅emc重組蛋白
貨號：

CSB-YP322441DLU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

黑腹果蠅emc重組蛋白
貨號：

CSB-EP322441DLU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

黑腹果蠅emc重組蛋白
貨號：

CSB-EP322441DLU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

黑腹果蠅emc重組蛋白
貨號：

CSB-BP322441DLU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

黑腹果蠅emc重組蛋白
貨號：

CSB-MP322441DLU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

emc
Uniprot No.：

P18491
別名：

emc; CG1007Protein extra-macrochaetae
種屬：

Drosophila melanogaster (Fruit fly)
蛋白長度：

full length protein
表達區域：

1-199
氨基酸序列

MKSLTAVCQT GASGMPALNA SGRIQRHPTH RGDGENAEMK MYLSKLKDLV PFMPKNRKLT KLEIIQHVID YICDLQTELE THPEMGNFDA AAALTAVNGL HEDEDSDMED ADAEAEAEVD PDILAQRLNA EQPAKVSSPA ARLPLTDRQT PNTLVAPAHP QQHQQQQQLQ LQQQQLQSQQ QLSNSLATPQ NAEKDSRQS
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Participates in sensory organ patterning by antagonizing the neurogenic activity of the Achaete-scute complex (AS-C). It lacks a basic DNA-binding domain but is able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding. May sequester proneural proteins in complexes inefficient for DNA interaction. EMC also affects vein differentiation. Inhibits the activity of AS-C proteins by forming an non-DNA binding heterodimer.
基因功能參考文獻：
1. Extramacrochaetae functions in dorsal-ventral patterning of Drosophila imaginal discs. PMID: 25715400
2. Hh drives and Emc impedes the progression of the furrow across the developing retina. PMID: 24406336
3. argue that the role emc, h and sr in development of the flight apparatus preceded their activities for macrochaete patterning PMID: 24384389
4. The role of Emc in eye development is to impose order on the retina by regulating the activity of the Hedgehog and Wingless signaling pathways. PMID: 23536565
5. These findings question whether hairy is an important regulator of the progression of retinal differentiation in Drosophila, alone or redundantly with extramacrochaete. PMID: 23118874
6. emc lies downstream of fs(1)K10, gurken and EGFR in the Grk/EGFR signalling pathway and it participates in controlling Broad-Complex expression at late stages of oogenesis. PMID: 16026970
7. Results show that extramacrochaetae is required for multiple aspects of eye development that depend on Notch signaling, including morphogenetic furrow progression, differentiation of R4, R7 and cone cell types, and rotation of ommatidial clusters. PMID: 19118542
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亞細胞定位：

Nucleus.
數據庫鏈接：

KEGG: dme:Dmel_CG1007

STRING: 7227.FBpp0072477

UniGene: Dm.2147