Recombinant Clostridium botulinum DNA integrity scanning protein DisA (disA)

中文名稱：

Recombinant Clostridium botulinum DNA integrity scanning protein DisA(disA)
貨號：

CSB-YP454819DUG
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Clostridium botulinum DNA integrity scanning protein DisA(disA)
貨號：

CSB-EP454819DUG
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Clostridium botulinum DNA integrity scanning protein DisA(disA)
貨號：

CSB-EP454819DUG-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Clostridium botulinum DNA integrity scanning protein DisA(disA)
貨號：

CSB-BP454819DUG
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Clostridium botulinum DNA integrity scanning protein DisA(disA)
貨號：

CSB-MP454819DUG
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

disA
Uniprot No.：

B2TIF1
別名：

disA; CLL_A0213DNA integrity scanning protein DisA; Cyclic di-AMP synthase; c-di-AMP synthase; Diadenylate cyclase; EC 2.7.7.85
種屬：

Clostridium botulinum (strain Eklund 17B / Type B)
蛋白長度：

full length protein
表達區域：

1-354
氨基酸序列

MRLEKGMKIK DTLKIMCPGT QLREGLENIL RAKTGGLIVI GDNKEVMDTV DGGFNLNSDY SPSYVYELAK MDGAIVISED LKKIVCANAQ LIPDPSIVTH ETGTRHRTAH RIAKQTNNIV IAISQRRNII TVYKGDIKYV LRDSSVILAR ANQAIQTLEK YVSVLERVIN NLNLLEFQDL TTLFDVVTAI QRTEMVMRIV EEINMYILEL GNEGRLISMQ LNELVKHIER DGILLIRDYC KDEDGHNEVY EQIQKLSATE LLDLDAIARV LGHAGESLVD TLISAKGYRI LGKVPRIPST VIENLIKEFK ELNSVIEADI DELDIVEGIG EARAKAIKDG LKRIREQILL NKKI
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Participates in a DNA-damage check-point that is active prior to asymmetric division when DNA is damaged. DisA forms globular foci that rapidly scan along the chromosomes during sporulation, searching for lesions. When a lesion is present, DisA pauses at the lesion site. This triggers a cellular response that culminates in a temporary block in sporulation initiation.; Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis.
蛋白家族：

DisA family
數據庫鏈接：

KEGG: cbk:CLL_A0213