Recombinant Chicken Proto-oncogene tyrosine-protein kinase Src (SRC), partial

中文名稱：

雞SRC重組蛋白
貨號：

CSB-YP022650CH
規(guī)格：
來源：

Yeast
其他：

中文名稱：

雞SRC重組蛋白
貨號：

CSB-EP022650CH
規(guī)格：
來源：

E.coli
其他：

中文名稱：

雞SRC重組蛋白
貨號：

CSB-EP022650CH-B
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

雞SRC重組蛋白
貨號：

CSB-BP022650CH
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

雞SRC重組蛋白
貨號：

CSB-MP022650CH
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

SRC
Uniprot No.：

P00523
別名：

SRC; Proto-oncogene tyrosine-protein kinase Src; EC 2.7.10.2; Proto-oncogene c-Src; pp60c-src; p60-Src
種屬：

Gallus gallus (Chicken)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy between members of the SRC kinase family, identification of the specific role of each SRC kinase is very difficult. SRC appears to be one of the primary kinases activated following engagement of receptors and plays a role in the activation of other protein tyrosine kinase (PTK) families. Receptor clustering or dimerization leads to recruitment of SRC to the receptor complexes where it phosphorylates the tyrosine residues within the receptor cytoplasmic domains. Plays an important role in the regulation of cytoskeletal organization through phosphorylation of specific substrates involved in this process. When cells adhere via focal adhesions to the extracellular matrix, signals are transmitted by integrins into the cell resulting in tyrosine phosphorylation of a number of focal adhesion proteins, including PTK2/FAK1 and paxillin (PXN). Also active at the sites of cell-cell contact adherens junctions and at gap junctions. Implicated in the regulation of pre-mRNA-processing. Might be involved not only in mediating the transduction of mitogenic signals at the level of the plasma membrane but also in controlling progression through the cell cycle via interaction with regulatory proteins in the nucleus. Involved in anchorage-independent cell growth.
基因功能參考文獻：
1. Data indicate a highly conserved amino acid, Gly449, that is necessary for Src kinase activation. PMID: 29255153
2. Therefore, Src is essential for viral replication in vitro and in ovo but is not required for infectious laryngotracheitis herpesvirus-induced cell death. PMID: 26446601
3. Calcium-permeable alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors trigger neuronal nitric-oxide synthase activation to promote nerve cell death in an Src kinase-dependent fashion PMID: 22992730
4. Activation of Src is a key mechanisms by which collagen I provokes capillary morphogenesis of microvascular endothelial cells PMID: 15003991
5. Formation of hemangiosarcomas in chick embryo required presence of src SH3 domain and, to some extent, SH2 domain; implicates distinct and opposite roles for SH2 and SH3 domains of src and cellular binding partners in tumorigenesis and hemorrhagic disease PMID: 16086237
6. protein kinase Src promotes translation by phosphorylating a key tyrosine residue in ZBP1 that is required for binding to RNA PMID: 16306994
7. Src is expressed in spinal lateral motor neurons of chick embryo at the time of limb trajectory selection. PMID: 19403835
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亞細胞定位：

Cell membrane; Lipid-anchor. Mitochondrion inner membrane. Endosome membrane; Peripheral membrane protein. Nucleus. Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Cytoplasm, perinuclear region.
蛋白家族：

Protein kinase superfamily, Tyr protein kinase family, SRC subfamily
組織特異性：

Expressed to high levels, and with a high degree of kinase activity, in certain fully differentiated cells such as neurons, platelets and macrophages. Isoform 1 is widely expressed. Isoform 2 is expressed only in the muscle.
數(shù)據(jù)庫鏈接：

KEGG: gga:396442

STRING: 9031.ENSGALP00000006117

UniGene: Gga.46254