Recombinant Bovine Tyrosine 3-monooxygenase (TH)

中文名稱：

牛TH重組蛋白
貨號：

CSB-YP023470BO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

牛TH重組蛋白
貨號：

CSB-EP023470BO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

牛TH重組蛋白
貨號：

CSB-EP023470BO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

牛TH重組蛋白
貨號：

CSB-BP023470BO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

牛TH重組蛋白
貨號：

CSB-MP023470BO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

TH
Uniprot No.：

P17289
別名：

TH; Tyrosine 3-monooxygenase; EC 1.14.16.2; Tyrosine 3-hydroxylase; TH
種屬：

Bos taurus (Bovine)
蛋白長度：

Full Length of Mature Protein
表達區域：

2-491
氨基酸序列

PTPNAASPQ AKGFRRAVSE LDAKQAEAIM SPRFVGRRQS LIQDARKERE KAEAAASSSE SAEAAAWLER DGEAVLTLLF ALPPTRPPAL TRAIKVFETF EAHLHHLETR PAQPLRAGSP PLECFVRCEV PGPVVPALLS ALRRVAEDVR AAGESKVLWF PRKVSELDKC HHLVTKFDPD LDLDHPGFSD QAYRQRRKLI AEIAFQYKQG DPIPHVEYTA EETATWKEVY STLRGLYPTH ACREHLEAFE LLERFCGYRE DRIPQLEDVS RFLKERTGFQ LRPAAGLLSA RDFLASLAFR VFQCTQYIRH ASSPMHSPEP ECCHELLGHV PMLADRTFAQ FSQDIGLASL GVSDEEIEKL STLYWFTVEF GLCKQNGEVK AYGAGLLSSY GELLHSLSEE PEIRAFDPDA AAVQPYQDQT YQPVYFVSES FSDAKDKLRS YASRIQRPFS VKFDPYTLAI DVLDSPHAIR HALDGVQDEM QALAHALNAI S
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Plays an important role in the physiology of adrenergic neurons. Positively regulates the regression of retinal hyaloid vessels during postnatal development.
基因功能參考文獻：
1. TH is a robust interaction partner of different 14-3-3 dimer types with moderate variability between the 14-3-3 dimers on their regulation of TH. PMID: 26825549
2. The sustained activation of TH that occurred as a result of TH phosphorylation at Ser40 could maintain the synthesis of catecholamines without the need for further stimulus of the adrenal cells or increased TH protein synthesis. PMID: 17261361
3. Retinol activates tyrosine hydroxylase via two sequential non-genomic mechanisms, which have not previously been characterized. These mechanisms are likely to operate in vivo to facilitate the stress response. PMID: 17908239
4. IFN-alpha mediated activation of ERK1/2 appeared to be responsible for the increased phosphorylation of tyrosine hydroxylase. PMID: 19207826
亞細胞定位：

Cytoplasm, perinuclear region.
蛋白家族：

Biopterin-dependent aromatic amino acid hydroxylase family
數據庫鏈接：

KEGG: bta:280707

STRING: 9913.ENSBTAP00000038050

UniGene: Bt.64937