Recombinant Bovine NAD-dependent protein deacylase sirtuin-5, mitochondrial (SIRT5)

中文名稱：

牛SIRT5重組蛋白
貨號：

CSB-YP669139BO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

牛SIRT5重組蛋白
貨號：

CSB-EP669139BO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

牛SIRT5重組蛋白
貨號：

CSB-EP669139BO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

牛SIRT5重組蛋白
貨號：

CSB-BP669139BO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

牛SIRT5重組蛋白
貨號：

CSB-MP669139BO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

SIRT5
Uniprot No.：

Q3ZBQ0
別名：

SIRT5; NAD-dependent protein deacylase sirtuin-5; mitochondrial; EC 2.3.1.-; Regulatory protein SIR2 homolog 5; SIR2-like protein 5
種屬：

Bos taurus (Bovine)
蛋白長度：

Full Length of Mature Protein
表達區域：

37-310
氨基酸序列

SSNM ADFRKCFAKA KHIVVISGAG ISAESGVPTF RGAGGYWRKW KAQDLATPQA FARNPSQVWE FYHYRREVVQ STEPNAGHLA IAECQARLHR QGRQVVVITQ NIDELHRKAG TKNLLEIHGS LFKTRCTSCG VVAENYKSPI CPALSGKGAP DPQTQDAGIP VEKLPRCEEA GCGGLLRPHV VWFGENLDPA ILEEVDKELA LCDLCLVVGT SSVVYPAAMF APQVSARGVP VAEFNMETTP ATERFRFHFQ GPCGTTLPEA LAPHETETVS
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Activates SHMT2 by mediating its desuccinylation. Modulates ketogenesis through the desuccinylation and activation of HMGCS2. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as UOX.
基因功能參考文獻：
1. Association analysis of individual SIRT5 SNPs and haplotype combinations reveal that the 4 loci are significantly associated with some body measurement and ultrasound traits in Qinchuan cattle. PMID: 25966154
亞細胞定位：

Mitochondrion. Cytoplasm, cytosol. Nucleus.
蛋白家族：

Sirtuin family, Class III subfamily
數據庫鏈接：

KEGG: bta:507347

STRING: 9913.ENSBTAP00000019842

UniGene: Bt.49500