Recombinant Bovine Multidrug resistance-associated protein 1 (ABCC1), partial

中文名稱：

Recombinant Bovine Multidrug resistance-associated protein 1(ABCC1) ,partial
貨號：

CSB-YP810222BO
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Bovine Multidrug resistance-associated protein 1(ABCC1) ,partial
貨號：

CSB-EP810222BO
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Bovine Multidrug resistance-associated protein 1(ABCC1) ,partial
貨號：

CSB-EP810222BO-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Bovine Multidrug resistance-associated protein 1(ABCC1) ,partial
貨號：

CSB-BP810222BO
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Bovine Multidrug resistance-associated protein 1(ABCC1) ,partial
貨號：

CSB-MP810222BO
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

ABCC1
Uniprot No.：

Q8HXQ5
別名：

ABCC1; MRP1; Multidrug resistance-associated protein 1; EC 7.6.2.2; ATP-binding cassette sub-family C member 1; Glutathione-S-conjugate-translocating ATPase ABCC1; EC 7.6.2.3; Leukotriene C(4) transporter; LTC4 transporter
種屬：

Bos taurus (Bovine)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs by decreasing accumulation of drug in cells, and by mediating ATP- and GSH-dependent drug export. Hydrolyzes ATP with low efficiency. Catalyzes the export of sphingosine 1-phosphate from mast cells independently of their degranulation. Participates in inflammatory response by allowing export of leukotriene C4 from leukotriene C4-synthezing cells.
基因功能參考文獻：
1. Using electron cryomicroscopy, authors determined the molecular structures of bovine MRP1 in two conformations: an apo form at 3.5 A without any added substrate and a complex form at 3.3 A with one of its physiological substrates, leukotriene C4; structures show that by forming a single bipartite binding site, MRP1 can recognize a of substrates with different chemical structures. PMID: 28238471
2. P-gp, Bcrp and Mrp1 are functionally expressed in bovine/rat co-culture model and model is suitable for investigations of small molecule transport. PMID: 24934296
亞細胞定位：

Cell membrane; Multi-pass membrane protein.
蛋白家族：

ABC transporter superfamily, ABCC family, Conjugate transporter (TC 3.A.1.208) subfamily
組織特異性：

Expressed in heart, spleen, lung, kidney, skeletal muscle, mammary gland and weaker in brain and liver.
數據庫鏈接：

KEGG: bta:281588

STRING: 9913.ENSBTAP00000028094

UniGene: Bt.88646