Recombinant Bovine 5'-AMP-activated protein kinase subunit gamma-3 (PRKAG3)

中文名稱：

牛PRKAG3重組蛋白
貨號：

CSB-YP643533BO
規格：
來源：

Yeast
其他：

中文名稱：

牛PRKAG3重組蛋白
貨號：

CSB-EP643533BO
規格：
來源：

E.coli
其他：

中文名稱：

牛PRKAG3重組蛋白
貨號：

CSB-EP643533BO-B
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

牛PRKAG3重組蛋白
貨號：

CSB-BP643533BO
規格：
來源：

Baculovirus
其他：

中文名稱：

牛PRKAG3重組蛋白
貨號：

CSB-MP643533BO
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

PRKAG3
Uniprot No.：

Q2LL38
別名：

PRKAG3; 5'-AMP-activated protein kinase subunit gamma-3; AMPK gamma3; AMPK subunit gamma-3
種屬：

Bos taurus (Bovine)
蛋白長度：

full length protein
表達區域：

1-497
氨基酸序列

MEPAELEHAL CGSLFSTQTP SWSSFGGPEH QEMSFLEQGD STSWPSPAMT TSAEISLGEQ RTKVSRWKSQ EDVEERELPG LEGGPQSRAA AESTGLEATF PKATPLAQAT PLSAVGTPTT ERDSLPADCT ASASSSSTDD LDQGIEFSAP AAWGDELGLV EERPAQCPSP QVPVLRLGWD DELRKPGAQV YMHFMQEHTC YDAMATSSKL VIFDTMLQIK KAFFALVANG VRAAPLWDSK KQSFVGMLTI TDFILVLHRY YRSPLVQIYE IEEHKIETWR EIYLQGCFKP LVSISPSDSL FEAVYTLIKN RIHRLPVLDP VSGAVLHILT HKRLLKFLHI FQRTLLPRPS FLYRTIQDLG IGTFRDLAVV LETAPILTAL DIFVDRRVSA LPVINEAGQV VGLYSRFDVI HLAAQQTYNH LDISVGEALR RRTLCLEGVL SCQPHETLGE VIDRIAREQV HRLVLVDETQ HLLGVVSLSD ILQALVLSPA GIDALGA
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. AMPK also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. The AMPK gamma3 subunit is a non-catalytic subunit with a regulatory role in muscle energy metabolism. It mediates binding to AMP, ADP and ATP, leading to AMPK activation or inhibition: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive.
基因功能參考文獻：
1. Association between polymorphism in bovine PRKAG3 gene and milk production traits. PMID: 21954624
蛋白家族：

5'-AMP-activated protein kinase gamma subunit family
數據庫鏈接：

KEGG: bta:511961

STRING: 9913.ENSBTAP00000017940

UniGene: Bt.42124