CC2D1A Recombinant Monoclonal Antibody
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中文名稱：CC2D1A Recombinant Monoclonal Antibody
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貨號：CSB-RA196860A0HU
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規格：￥1320
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圖片：
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Flow cytometric analysis of CC2D1A expression in C2C12 cells using CC2D1A antibody. Green, isotype control; red, CC2D1A. -
Immunocytochemical staining of HepG2 cells with CC2D1A antibody. Nuclei were stained blue with DAPI; CC2D1A was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar, 20 μm. -
Western blotting analysis using CC2D1A antibody. Total cell lysates (20 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with CC2D1A antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
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其他：
產品詳情
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Uniprot No.：
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基因名：CC2D1A
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別名：CC2D1A; Coiled-Coil And C2 Domain Containing 1A; Five Prime Repressor Element Under Dual; Repression-Binding Protein 1; Akt Kinase-Interacting Protein 1; MRT3; TAPE; Coiled-Coil And C2 Domain-Containing Protein 1A; FRE Under Dual Repression-Binding Protein 1; Putative NF-Kappa-B-Activating Protein 023N; TBK1-Associated Protein In Endolysosomes 2; Lethal (2) Giant Discs Homolog 2; FLJ20241; Freud-1; FREUD-1; Aki-1; Lgd2; Five Repressor Element Under Dual Repression-Binding Protein 1; Mental Retardation, Nonsyndromic, Autosomal Recessive, 3; Putative NFkB Activating Protein; Freud-1/Aki1; AKI-1; LGD2; AKI1
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反應種屬：Human, Mouse, Rat
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免疫原：Recombinant Human CC2D1A protein
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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克隆類型：Monoclonal
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抗體亞型：Rabbit IgG
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純化方式：Affinity-chromatography
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克隆號：3F4
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Rabbit IgG in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
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產品提供形式：Liquid
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應用范圍：ELISA, WB, FC, ICC
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推薦稀釋比：
Application Recommended Dilution WB 1:1000-1:5000 FC 1:200-1:2000 ICC 1:100-1:1000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of HTR1A associated with anxiety and major depression. Mediates HDAC-independent repression of HTR1A promoter in neuronal cell. Performs essential function in controlling functional maturation of synapses. Plays distinct roles depending on its localization. When cytoplasmic, acts as a scaffold protein in the PI3K/PDK1/AKT pathway. Repressor of HTR1A when nuclear. In the centrosome, regulates spindle pole localization of the cohesin subunit SCC1/RAD21, thereby mediating centriole cohesion during mitosis.
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基因功能參考文獻：
- Both expressions of CC2D1A and HTR1A genes studied on autism spectrum disorder cases and controls were significantly different PMID: 26782176
- CC2D1A binds to CHMP4B polymers formed on endosomes to regulate the endosomal sorting pathway.CC2D1A regulates degradation and signaling of EGFR and TLR4. PMID: 27769858
- Aki1 was expressed in human diffuse malignant mesothelioma specimens. Expression correlated with phosphorylated CREB1. Aki1 regulates CREB by modulating protein kinase A activity. The Aki1-CREB axis plays an important role in DMM pathogenesis. PMID: 26294214
- Null mutations in CC2D1A consistently cause a variable spectrum of presentations including ID, ASD, and seizures. CC2D1A regulates NF-kappaB signaling. PMID: 25066123
- All of the pancreatic cancer cell lines expressed Aki1. Silencing of Aki1 in Panc1 cells reduced the phosphorylation of Akt and increased the phosphorylation of cleaved PARP. PMID: 25036909
- Non-genomic downregulation of 5-HT1A receptor by 17betaestradiol does not involve NUDR and Freud-1 proteins. PMID: 22328058
- TBK1-associated protein in endolysosomes (TAPE)/CC2D1A is a key regulator linking RIG-I-like receptors to antiviral immunity PMID: 22833682
- CHMP4B interacts directly with CC2D1A and CC2D1B with nanomolar affinity by forming a 1:1 complex. PMID: 22406677
- CC2D1A interaction with CHMP4B/4A blocks HIV-1 budding. PMID: 22258254
- Results suggest the involvement of CC2D1A and CC2D2A in mental retardation in the Han Chinese population, and some specific haplotypes may be susceptible or protective. PMID: 22023432
- Reductions in Freud-1 expression in prefrontal cortex may be associated with early onset of major depressive disorder. PMID: 20392296
- Data suggest that the anti-tumor activity of NF-kappaB inhibitors is associated with p53-mediated activation of autophagy. PMID: 21274377
- central role for TAPE (CC2D1A/Freud-1/Aki-1)in linking TLR3 and TLR4 to innate immune defenses at an early step PMID: 21189260
- CC2D1A activates NF-kappaB through the canonical IKK pathway PMID: 20529849
- these results indicate that cyclin B1-Cdk1 is a kinase of Aki1 during mitosis and that its phosphorylation of Aki1 may regulate mitotic function. PMID: 20171170
- Centrosome-associated Aki1 and cohesin play pivotal roles in preventing premature cleavage in centriole cohesion. PMID: 19948489
- A protein truncating mutation was identified in the gene CC2D1A in nine consanguineous families with severe autosomal recessive mental retardation. PMID: 16033914
- a deletion in the CC2D1A gene has been linked to nonsyndromic mental retardation. This deletion results in the truncation of the helix-loop-helix DNA binding and the C2 domains. PMID: 17394259
- Freud-1 has a key role in regulating DRD2 expression PMID: 17535813
- disruption of transcriptional regulation by mutation of Freud-1 may play a role in abnormal brain function leading to mental retardation PMID: 17714190
- Results suggest that Freud-1/Aki1 is a novel receptor-selective scaffold protein for the PDK1/Akt pathway and present a new activation mechanism of Akt. PMID: 18662999
- Aki1 (Akt kinase-interacting protein 1)/CC2D1A/Freud-1 localized in centrosomes in addition to cytosol and in nucleus. Aki1 interacts with cohesin to prevent premature separase-mediated centriole disengagement. PMID: 19948489
- CC2D1A associated with epidermal growth factor receptor (EGFR) in response to EGF stimulation, and was required for Akt activation induced by EGF, but not by insulin-like growth factor 1 (IGF-1). PMID: 18662999
- Paper describes a function of Cc2d1a/Cc2d1b and their Drosophila homologue l(2)gd in D.melanogaster in Notch trafficking. PMID: 17084358
- Review of Freud-1 as a repressor of serotonin 1A receptor gene. PMID: 15534042
- Freud-1 mediates HDAC-independent repression of the 5-HT1A receptor promoter in neuronal 5-HT1A-positive cells. PMID: 14756806
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相關疾?。?/div>Mental retardation, autosomal recessive 3 (MRT3)亞細胞定位：Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.蛋白家族：CC2D1 family數據庫鏈接：
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