Recombinant Rat cAMP-dependent protein kinase type II-beta regulatory subunit (Prkar2b)

說明書

中文名稱：

大鼠Prkar2b重組蛋白
貨號：

018698RA
規格：
其他：

產品詳情
產品評價
靶點詳情

產品詳情

Uniprot No.：

P12369
基因名：

Prkar2b
別名：

Prkar2bcAMP-dependent protein kinase type II-beta regulatory subunit
免疫原種屬：

Rattus norvegicus (Rat)
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
應用說明：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
儲存條件：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.
基因功能參考文獻：
1. Release of pRIIbeta in the presence of cAMP is reduced by calcium, whereas autophosphorylation at the phosphorylation site inhibits holoenzyme reassociation with the catalytic subunit. PMID: 26158466
2. The unique structural properties of RiIbeta do not require the C-terminal cAMP-binding domain. PMID: 25112875
3. study describes the 2.3 angstrom structure of full-length tetrameric RIIbeta(2):C(2) holoenzyme PMID: 22323819
4. the B domain of type II beta regulatory subunit of cAMP-dependent protein kinase inhibits holoenzyme activation for RIIbeta PMID: 14625280
5. Direct evidence is provided that the type II beta protein kinase A regulatory subunit may be partially associated with the type I alpha catalytic subunit with the pseudosubstrate sequence docked in the active site cleft in the presence of cAMP. PMID: 14967031
6. InsP3R1 forms a complex with AKAP450 and PKAIIbeta, localized in the Golgi apparatus of cerebellar granule cells. PMID: 19236309
7. The novel orientation of the linker peptide provides the first clues as to how this region contributes to the unique organization of the RIIbeta holoenzyme. PMID: 19748511
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亞細胞定位：

Cytoplasm. Cell membrane.
蛋白家族：

CAMP-dependent kinase regulatory chain family
組織特異性：

Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible. Brain. Present in a few pyramidal neurons and mostly in mossy fibers. Coloc
數據庫鏈接：

KEGG: rno:24679

STRING: 10116.ENSRNOP00000012415

UniGene: Rn.164375