Recombinant Mouse Serum amyloid P-component (Apcs)

說明書

中文名稱：

Recombinant Mouse Serum amyloid P-component(Apcs)
貨號：

001898MO
規格：
其他：

產品詳情
產品評價
靶點詳情

產品詳情

Uniprot No.：

P12246
基因名：

Apcs
別名：

Apcs; Ptx2; Sap; Serum amyloid P-component; SAP
免疫原種屬：

Mus musculus (Mouse)
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
應用說明：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
儲存條件：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

基因功能參考文獻：
1. SAP deficiency mitigated foam cell formation and atherosclerotic development in apoE(-/-) mice, due to reduction in macrophages recruitment, polarization and pro-inflammatory cytokines PMID: 26649902
2. Data suggest that serum amyloid P (SAP) activates CD209 DC-SIGN to regulate the innate immune system differently from C-reactive protein (CRP), and that DC-SIGN is a target for antifibrotics. PMID: 26106150
3. observations suggest that serum amyloid P, at least in part, uses FcgammaRI and FcRgamma to inhibit fibrocyte differentiation PMID: 22493081
4. Bglu3 is confirmed to be a locus affecting diabetes susceptibility, and Apcs is a probable candidate gene. PMID: 22274563
5. binding of SAP to ALD-DNA could switch macrophage phenotypic polarization from proinflammatory M2b to anti-inflammatory M2a via PI3K/Akt-ERK signaling activation, thus exerting protective and therapeutic interventions on murine lupus nephritis PMID: 21753147
6. SAP has an effect on macrophages in fibrotic lung disease PMID: 20300636
7. sFRP4 negatively regulates bone formation without disrupting phosphorus homeostasis. PMID: 20472109
8. Serum amyloid P is elevated in the urine and kidneys of mice during anti-glomerular basement membrane disease, as well as in mice with spontaneously arising lupus nephritis. PMID: 20065116
9. Binding of mouse and human SAP to immobilized influenza virus was compared. Mouse SAP bound much less avidly than human SAP.mouse SAP apparently plays no significant role during infection of mice with influenza virus. PMID: 11984001
10. Targeted pharmacological depletion of serum amyloid P component for treatment of amyloidosis PMID: 12015594
11. during murine tuberculosis (TB) SAP levels were increased; purified mouse SAP inhibited the intra-alveolar macrophage M. tuberculosis growth, in vitro; SAP may thus contribute both to the pathogenesis and pulmonary innate immunity in TB PMID: 16298151
12. SAP may modulate the inflammatory response to amyloid fibrils in atherosclerosis PMID: 17630380
13. These results show a novel and physiologically significant role for SAP for complement-mediated immunity against an important bacterial pathogen, and provide further evidence for the importance of the classical complement pathway for innate immunity. PMID: 17845072
14. Cells sensing they are inflicted with mortal injury can turn on molecular programs insuring not only that they die by apoptosis but also that once they are dead their elimination is (facilitated by SAP) swift and efficient. PMID: 18046483
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相關疾病：

SAP is a precursor of amyloid component P which is found in basement membrane and associated with amyloid deposits.
亞細胞定位：

Secreted.
蛋白家族：

Pentraxin family
數據庫鏈接：

KEGG: mmu:20219

STRING: 10090.ENSMUSP00000027824

UniGene: Mm.330510