Recombinant Rat Cysteine-rich secretory protein 1 (Crisp1)

說明書

中文名稱：

Recombinant Rat Cysteine-rich secretory protein 1(Crisp1)
貨號：

005974RA
規格：
其他：

產品詳情
產品評價
靶點詳情

產品詳情

Uniprot No.：

P12020
基因名：

Crisp1
別名：

Crisp1; AegCysteine-rich secretory protein 1; 32 kDa epididymal protein; Acidic epididymal glycoprotein; Protein D; Protein E; Protein IV; Sialoprotein; Sperm-coating glycoprotein; SCP
免疫原種屬：

Rattus norvegicus (Rat)
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
應用說明：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
儲存條件：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

This protein is supposed to help spermatozoa undergo functional maturation while they move from the testis to the ductus deferens.
基因功能參考文獻：
1. involvement of CRISP1-Zn(2+) complexes in the association of the loosely bound population of CRISP1 with sperm during epididymal maturation PMID: 21593480
2. In addition to its influence on protein tyrosine phosphorylation, bicarbonate is required to support other rat sperm capacitation-associated events, such as migration of CRISP-1 to equatorial segment, and expression of ability of sperm to fuse with egg. PMID: 14711787
3. the egg-binding ability of CRISP1 resides within a 45-amino acid N-terminal region containing the two motifs of the CRISP family named Signature 1 and Signature 2, the binding site of CRISP1 resides in an evolutionarily conserved region PMID: 16872593
4. Recombinant Crisp1 is able to elicit a specific immune response and inhibit male and female fertility, supporting the use of this sperm epididymal protein for the development of an immunocontraceptive approach. PMID: 17482178
5. CRISP1 participates not only in sperm-egg fusion but also in the prior stage of sperm-ZP interaction. PMID: 17671267
6. CRISP1 interacts with sperm transiently, possibly with a specific receptor on the sperm surface, consistent with its action in suppressing capacitation during epididymal storage of sperm PMID: 18703418
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亞細胞定位：

Secreted.
蛋白家族：

CRISP family
組織特異性：

Secreted by the epididymal epithelium and then becomes associated with the sperm surface.
數據庫鏈接：

KEGG: rno:64827

STRING: 10116.ENSRNOP00000018162

UniGene: Rn.10102